1,2-Diiodotetrafluoroethane

CAS 354-65-4

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$7M

Top sourceJapan 92%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 290378 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 290378, which covers 18 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

JP 92%JapanCN 3%ChinaKR 3%South KoreaIN 2%India

Israel
Russia

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Chemours

Why It Matters

Sectors

Core Chemicals

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Intermediate in All Other Basic Organic Chemical Manufacturing (100%)Processing as a reactant

Vendor Pricing

$5.80/gCombi-Blocks, Inc.

CountryUnited States

Pack$580.00 / 100 g

Purity98%

Vendors6 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

5 more vendors

Vendor	Country	$/g	Pack	Purity
A2B Chem LLC	United States	$6.17	100 g	98%
AA BLOCKS	United States	$6.52	100 g	98%
Manchester Organics	United Kingdom	$6.84	100 g	—
ALFA AESAR	Germany	$67.92	1 g	96%
Fluorochem UK	United Kingdom	$89.89	1 g	97%

Chemical Identity

CAS354-65-4

PubChem CID67720

DTXSIDDTXSID5073165

FormulaC2F4I2

Mol. Weight353.82 g/mol

SMILESC(C(F)(F)I)(F)(F)I

Data Sources

EPA CompTox (DSSTox) · DTXSID5073165Retrieved 2026-04-06
PubChem · compound 67720Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

1,2-Diiodotetrafluoroethane (CAS 354-65-4) https://chemicalindependence.com/chemical/354-65-4/ EPA CompTox (DSSTox): DTXSID5073165. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID5073165 PubChem: 67720. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/67720 EPA Chemical Data Reporting: 354-65-4. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 354-65-4. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 290378 for CAS 354-65-4. Reporting year: 2024. https://usatrade.census.gov/