1-Chloro-1,1,2,2-tetrafluoroethane

CAS 354-25-6

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$56M

Top sourceIndia 51%

At least one company claimed its 2019 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2019. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 290379 · basket

EPA reports by year

2019: US production Confidential · Imports Confidential

These shares come from HS customs code 290379, which covers 34 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IN 51%IndiaCN 38%ChinaJP 11%JapanMX 1%Mexico

United Kingdom

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Chemours

Why It Matters

Sectors

Core Chemicals

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Functional fluids (closed systems) in All Other Chemical Product and Preparation Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product

Chemical Identity

CAS354-25-6

PubChem CID9632

DTXSIDDTXSID1042023

FormulaC2HClF4

Mol. Weight136.47 g/mol

SMILESC(C(F)(F)Cl)(F)F

Data Sources

EPA CompTox (DSSTox) · DTXSID1042023Retrieved 2026-04-06
PubChem · compound 9632Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2019 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2019 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

1-Chloro-1,1,2,2-tetrafluoroethane (CAS 354-25-6) https://chemicalindependence.com/chemical/354-25-6/ EPA CompTox (DSSTox): DTXSID1042023. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID1042023 PubChem: 9632. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/9632 EPA Chemical Data Reporting: 354-25-6. Reporting year: 2019. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 354-25-6. Reporting year: 2019. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 290379 for CAS 354-25-6. Reporting year: 2024. https://usatrade.census.gov/