estradiol hemihydrate
Drug ingredientCAS 35380-71-3
This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.
US productionNot reported
Top sourceNo public record
This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.
Why supply is unknownWhere It Comes From
EPA and Census publish no US supply data for this chemical.
24 FDA-registered drug labelers
A-S Medication Solutions
Alvogen Inc.
ASG Biochem Pvt. LTD.
Aurobindo Pharma Limited
Bayer AG
Bryant Ranch Prepack
COHESION BIOTEC PRIVATE LIMITED
Elanco US Inc.
Encube Ethicals, Inc.
F.I.S. FABBRICA ITALIANA SINTETICI S.P.A.
Hubei Gedian humanwell Pharmaceutical Co., Ltd
Kalchem International inc
La Chandra Pharmalab Private Limited
LETCO MEDICAL, LLC
NorthStar Rx LLC
Patheon, Inc.
Pharma Source Direct, Inc.
Professional Compounding Centers of America
SCH Global Services Private Limited
Spectrum Laboratory Products, Inc.
Sumitomo Pharma America, Inc
Symbiotec Pharmalab Limited
Valdepharm
zhejiang xianju pharmaceutical co., Ltd.
Why It Matters
Sectors
Health
Downstream Uses
Appears in 4 drug and cosmetic product listings (FDA).
- •Estradiol
- •Estradiol Vaginal Inserts
- •Estradiol Vaginal
- •Myfembree
FDA Shortage Status
Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."
No FDA shortage records
Chemical Identity
CAS35380-71-3
PubChem CID154274
DTXSIDDTXSID60858948
FormulaC36H50O5
Mol. Weight562.8 g/mol
SMILESCC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O.CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O.O
Data Sources
- PubChem · compound 154274Retrieved 2026-04-07
- FDA National Drug Code directoryRetrieved 2026-04-25
- FDA National Drug Code directoryRetrieved 2026-04-07
Brief citations
estradiol hemihydrate (CAS 35380-71-3) https://chemicalindependence.com/chemical/35380-71-3/ PubChem: 154274. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/154274 FDA National Drug Code directory: CAS 35380-71-3. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/