Ketotifen fumarate

Drug ingredient

CAS 34580-14-8

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$6.4B

Top sourceSingapore 36%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293499 · basket

These shares come from HS customs code 293499, which covers 575 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

SG 36%SingaporeIE 23%IrelandCN 11%ChinaCH 6%SwitzerlandIN 5%India

Finland
Netherlands
Canada
Indonesia
Mexico
Taiwan
South Korea
Austria
Croatia
Sweden
Ukraine
Denmark
Israel
Czech Republic
New Zealand
Hong Kong
Kyrgyzstan
Australia
Portugal
South Africa
Poland
Slovenia
Brazil
Slovakia
Vietnam
Latvia
Malta
Hungary
Romania
Kenya
Belarus
Russia
Turkey
Norway

28 FDA-registered drug labelers

A-S Medication Solutions

Alcon Laboratories, Inc.

Armas Pharmaceuticals Inc.

Bausch & Lomb Incorporated

Cardinal Health

CARDINAL HEALTH 110, LLC. DBA LEADER

CVS Pharmacy

DARMERICA, LLC

KALINTIS HEALTHCARE PRIVATE LIMITED

Kroger Company

LETCO MEDICAL, LLC

MEDISCA Inc.

Olon SpA

PERRIGO DIRECT INC.

Preferred Pharmaceuticals Inc.

Professional Compounding Centers of America

Proficient Rx LP

Rite Aid Corporation

Rugby Laboratories

Safeway

Spectrum Laboratory Products, Inc.

Target Corporation

TOPCO ASSOCIATES LLC

Unichem Pharmaceuticals (USA), Inc.

Wal-Mart Stores, Inc.

Walgreen Company

ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.

Zhejiang Supor Pharmaceuticals Co., Ltd

Why It Matters

Sectors

Health

Downstream Uses

Appears in 7 drug and cosmetic product listings (FDA).

•Zaditor
•Eye Itch Relief
•Eye Itch Releif
•Ketotifen Fumarate
•Ketotifen Fumarate Ophthalmic Solution
•Alaway
•Equate Eye Itch Relief

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$12.96/gAA BLOCKS

CountryUnited States

Pack$324.00 / 25 g

Purity95%

Vendors3 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

2 more vendors

Vendor	Country	$/g	Pack	Purity
Aaron Chemicals LLC	Hong Kong	$16.20	25 g	95%
Apexbio Technology LLC	United States	$67.00	1 g	98%

Chemical Identity

CAS34580-14-8

PubChem CID5282408

DTXSIDDTXSID30892970

FormulaC23H23NO5S

Mol. Weight425.5 g/mol

SMILESCN1CCC(=C2C3=C(C(=O)CC4=CC=CC=C42)SC=C3)CC1.C(=CC(=O)O)C(=O)O

Data Sources

PubChem · compound 5282408Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Ketotifen fumarate (CAS 34580-14-8) https://chemicalindependence.com/chemical/34580-14-8/ PubChem: 5282408. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5282408 FDA National Drug Code directory: CAS 34580-14-8. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293499 for CAS 34580-14-8. Reporting year: 2024. https://usatrade.census.gov/