pseudoephedrine hydrochloride
Drug ingredientCAS 345-78-8
This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.
US productionNot reported
Import value, 2024$6M
Top sourceGermany 73%
This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.
Why supply is unknownProduction is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.
Where It Comes From
Customs basis: HS 293942 · basket
These shares come from HS customs code 293942, which covers 3 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.
Source Countries
Country of origin for US imports, from Census customs data (2024).
DE 73%GermanyIN 27%India
97 FDA-registered drug labelers
A-S Medication Solutions
Acella Pharmaceuticals, LLC
ACTIPHARMA, LLC
Allegis Pharmaceuticals, LLC
American Sales Company
AmeriSource Bergen
Ascend Laboratories, LLC
Aurobindo Pharma Limited
Aurohealth LLC
Bayer HealthCare LLC.
Better Living Brands LLC
BIONPHARMA INC.
Bryant Ranch Prepack
Capital Pharmaceutical, LLC
CARDINAL HEALTH
CARDINAL HEALTH 110, LLC DBA LEADER
Catalent Pharma Solutions, LLC
Centurion Labs, LLC
Chain Drug Consortium
CHAIN DRUG CONSORTIUM,LLC
CHAIN DRUG MARKETING ASSOCIATION INC
Chartwell Governmental & Specialty RX, LLC
Chartwell RX, LLC
Chattem, Inc.
Cheng Fong Chemical Co., Ltd.
Costco Wholesale Company
CVS Health Corp
CVS PHARMACY
CVS Pharmacy, Inc
CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED
DISCOUNT DRUG MART
Dr. Reddy's Laboratories Inc.
Dr. Reddy's Laboratories Limited
Dr. Reddy's Labratories Inc.
EDWARDS PHARMACEUTICALS, INC.
Embio Limited
Eywa Pharma Inc
GM Pharmaceuticals, INC
Granules India Ltd
H E B
Haleon US Holdings LLC
Kenvue Brands LLC
Kenvue Canada Inc.
KROGER COMPANY
L. Perrigo Company
L.N.K. International, Inc.
Larken Laboratories, Inc.
Llorens Pharmaceutical International Division
Llorens Pharmaceutical International Division, Inc.
LLORENS PHARMACEUTICALS INTERNATIONAL DIVISION
Magna Pharmaceuticals, Inc.
Major Pharmaceuticals
Malladi Drugs & Pharmaceuticals Limited
Meijer
Meijer Distribution Inc
Meijer, Inc.
Ohm Laboratories Inc.
Padagis Israel Pharmaceuticals Ltd
Padagis US LLC
PAI Holdings, LLC dba PAI Pharma
Patheon Manufacturing Services LLC
Patheon Softgels Inc.
Poly Pharmaceuticals, Inc.
Professional Compounding Centers of America
Professional Compounding Centers of America dba PCCA
Proficient Rx LP
PUBLIX SUPER MARKETS, INC
R. A. McNeil Company
RB Health (US) LLC
REMEDYREPACK INC.
RITE AID
Rite Aid Corporation
Rugby Laboratories
RUGBY LABORATORIES, INC.
Safeway
Safeway Inc.
SAM'S WEST INC
Sanofi Winthrop Industrie
Siegfried PharmaChemikalien Minden GmbH
Sportpharm LLC
Strategic Sourcing Services
STRATEGIC SOURCING SERVICES LLC
Sun Pharmaceutical Industries, Inc.
The Kroger Co.
The Kroger Company
The Procter & Gamble Manufacturing Company
Topco Associates LLC
UCB Pharma SA
United Natural Foods, Inc. dba UNFI
VESPYR BRANDS, INC.
Wal-Mart Stores Inc
WALGREEN CO.
WALGREEN COMPANY
walgreens
Walgreens Company
WALMART INC.
Zhejiang Apeloa Kangyu Pharmaceutical Co., Ltd.
Why It Matters
Sectors
Health
Downstream Uses
Appears in 124 drug and cosmetic product listings (FDA).
- •Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide
- •Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride
- •Vicks NyQuil-D COLD and Sinus plus Severe Congestion
- •SudoGest
- •Mucus Relief D
- •sinus 12 hour
- •CareOne Nasal and Sinus Decongestant
- •Brompheniramine Maleate, Pseudoephedrine Hydrochloride, Dextromethorphan Hydrobromide
Show all 124
- •Sinus and Congestion Non-Drowsy
- •Poly-Vent IR
- •Durahist
- •Tusnel
- •Ibuprofen and Pseudoephedrine Hydrochloride
- •Vanacof
- •Mucinex D Maximum Strength
- •Pseudoephedrine Hydrochloride
- •Allergy relief-D
- •12 Hour Nasal Decongestant
- •Leader Mucus Relief D
- •nasal decongestant
- •Guaifenesin D
- •Histex-DM New Formulation
- •Topcare Sinus and Cold D
- •nasal decongestant maximum strength non drowsy
- •Guaifenesin and Pseudoephedrine Hydrochloride
- •Sudafed Sinus Congestion 12 Hour
- •Zyrtec-D
- •Naproxen Sodium and Pseudoephedrine Hydrochloride Sinus and Cold
- •Guaifenesin and Pseudoephedrine HCl
- •Acticon Pediatric
- •Acticon
- •Mucinex D
- •Brompheniramine, Pseudoephedrine, Dextromethorphan
- •All Day Sinus and Cold D
- •Leader Nasal Decongestant
- •Leader Allergy Relief D
- •Ibuprofen and Pseudoephedrine HCl
- •Naproxen Sodium AND Pseudoephedrine Hydrochloride COLD AND Sinus
- •Rugby Cetirizine Hydrochloride and Pseudoephedrine Hydrochloride
- •topcare mucus d
- •Advil COLD AND Sinus
- •Advil Allergy Sinus
- •Theraflu-D Flu Relief Max Strength plus Nasal Decongestant Nighttime
- •Fexofenadine HCl and Pseudoephedrine HCl
- •good sense all day allergy d
- •Allergy and Sinus Relief
- •Equaline 12 Hour Decongestant
- •Sinus and Cold D
- •Aprodine
- •Poly-Vent DM
- •Sinus AND Nasal Decongestant
- •Tusnel C
- •Conex
- •Nasal Decongestant Non-Drowsy
- •Nasal Decongestant Maximum Strength
- •Foster AND Thrive Allergy AND Congestion D
- •Mucus D
- •Sinus Congestion
- •Vicks DayQuil-D COLD and Sinus plus Severe Congestion
- •Good Sense Suphedrine 12 Hour
- •Good Sense Nasal Decongestant
- •all day allergy d
- •Fexofenadine HCl and Pseudoephedrine HCI
- •Allegra-D Allergy and Congestion
- •12 hour allergy d
- •Sudogest Nasal Decongestant
- •Aleve-D Sinus and Cold
- •Cold and Allergy D
- •Rynex PSE
- •sinus pressure and congestion relief maximum strength
- •good neighbor pharmacy nasal decongestant
- •topcare all day allergy d
- •Cetirizine hydrochloride and Pseudoephedrine hydrochloride
- •Allergy Relief D12
- •Maximum Strength Mucus D
- •Naproxen Sodium and Pseudoephedrine Hydrochloride Sinus and Headache
- •Wal-Zyr D
- •Nasal Decongestant D
- •Leader 12 Hour Sinus Nasal Decongestant
- •Rugby Mucus Relief D
- •equate mucus d
- •Pseudoephedrine HCl
- •Allergy and Congestion
- •Histanaz
- •Capmist DM
- •equate sinus 12 hour
- •Extra Strength Tylenol Cold Plus Flu Multi-Action Day
- •Actinel
- •Theraflu-D Flu Relief Max Strength plus Nasal Decongestant
- •SudoGest 12 Hour
- •Chlo Tuss
- •signature care allergy relief d
- •Ninjacof-D
- •good neighbor pharmacy all day allergy d
- •Sudafed Sinus 12 Hour Pressure plus Pain
- •Duraflu
- •Stahist AD
- •Actinel Pediatric
- •foster and thrive mucus relief d
- •M-END DMX
- •sinus
- •Sinus Decongestion
- •Topcare Nasal Decongestant Maximum Strength Non Drowsy
- •Zyrtec-D Allergy Plus Congestion
- •Duratuss DM
- •Tusnel DM Pediatric
- •Conex Pediatric
- •equate allergy relief d nasal decongestant
- •Allegra-D
- •Sudafed Sinus Congestion
- •Tusnel Pediatric
- •kirkland signature aller tec d
- •LoHist D
- •Leader All Day Sinus and Cold D
- •Zephrex D
- •topcare 12 hour decongestant
- •equaline nasal decongestant non drowsy maximum strength
- •Childrens Sudafed Nasal Decongestant
- •Triponel
- •Actispec PSE
- •Aleve-D Sinus and Headache
- •leader 12 hour nasal decongestant
- •Foster AND Thrive ALL DAY Allergy D
- •Brompheniramine maleate, pseudoephedrine hydrochloride,
FDA Shortage Status
Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."
No FDA shortage records
Chemical Identity
CAS345-78-8
PubChem CID9581
DTXSIDDTXSID10889343
FormulaC10H16ClNO
Mol. Weight201.69 g/mol
SMILESCC(C(C1=CC=CC=C1)O)NC.Cl
Data Sources
- PubChem · compound 9581Retrieved 2026-04-07
- EPA TSCA InventoryRetrieved 2026-04-24
- FDA National Drug Code directoryRetrieved 2026-04-07
- US Census international tradeReporting year: 2024 · Retrieved 2026-10-04
Brief citations
pseudoephedrine hydrochloride (CAS 345-78-8) https://chemicalindependence.com/chemical/345-78-8/ PubChem: 9581. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/9581 EPA TSCA Inventory: CAS 345-78-8. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293942 for CAS 345-78-8. Reporting year: 2024. https://usatrade.census.gov/