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lubiprostone

Drug ingredient

CAS 333963-40-9

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 333963-40-9
US productionNot reported
Import value, 2024$28M
Top sourceItaly 33%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293750 · basket

These shares come from HS customs code 293750, which covers 11 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IT 33%ItalyTW 27%TaiwanKR 14%South KoreaHU 13%HungaryGB 4%United Kingdom
27 FDA-registered drug labelers
Advanced Rx of Tennessee, LLC
American Health Packaging
Asclemed USA, Inc.
Camber Pharmaceuticals, Inc.
Catalent Pharma Solutions, LLC
Chirogate International Inc
Direct Rx
Dr. Reddy's Laboratories Inc.
Dr.Reddy's Laboratories Limited
Everlight Chemical Industrial Corporation Kuanyin II Plant
Golden State Medical Supply, Inc.
MSN Laboratories Private Limited
Natco Pharma USA LLC
Northstar Rx LLC
Par Health USA, LLC
Patheon Softgels Inc.
Proficient Rx LP
Quality Care Products, LLC
SpecGx LLC
SUCAMPO PHARMA LIMITED LIABILITY COMPANY
Sun Pharmaceutical Industries, Inc.
Takeda Pharmaceuticals America, Inc.
Teva Pharmaceuticals, Inc.
YS Life Science Co., Ltd.
Zhejiang Ausun Pharmaceutical Co., Ltd.
Zydus Lifesciences Limited
Zydus Pharmaceuticals USA Inc.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

  • •Lubiprostone
  • •Amitiza
  • •Amitza
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS333963-40-9
PubChem CID157920
DTXSIDDTXSID80861338
FormulaC20H32F2O5
Mol. Weight390.5 g/mol
SMILESCCCCC(C1(CCC2C(O1)CC(=O)C2CCCCCCC(=O)O)O)(F)F

Data Sources

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Brief citations

lubiprostone (CAS 333963-40-9) https://chemicalindependence.com/chemical/333963-40-9/ PubChem: 157920. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/157920 FDA National Drug Code directory: CAS 333963-40-9. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293750 for CAS 333963-40-9. Reporting year: 2024. https://usatrade.census.gov/