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α-ketoglutaric acid

Drug ingredient

CAS 328-50-7

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 328-50-7
US productionNot reported
Import value, 2024$65M
Top sourceChina 20%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291830 · basket

These shares come from HS customs code 291830, which covers 98 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
CN 20%ChinaIN 19%IndiaIT 19%ItalyCH 15%SwitzerlandJP 15%Japan
7 FDA-registered drug labelers
BioActive Nutritional, Inc.
BioActive Nutritionals, Inc.
Deseret Biologicals, Inc.
Dr. Donna Restivo DC
Energetix Corporation
Guna spa
Pro Weight Loss Inc.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 13 drug and cosmetic product listings (FDA).

  • •GUNA Arthro Relief
  • •Diathesis V 1
  • •Thyro-Chord
  • •GUNA-Dizzy
  • •Thyro Support
  • •Omeosport
  • •Free Radical
  • •Diathesis I
Show all 13
  • •D1 Organ Support
  • •GUNA-Arthro
  • •Energize
  • •Diathesis III
  • •Metabolism
FDA Shortage Status
No FDA shortage records

Vendor Pricing

$0.04/gAaron Chemicals LLC
CountryHong Kong
Pack$417.00 / 10 kg
Purity99%
Vendors34 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

33 more vendors
VendorCountry$/gPackPurity
Angene ChemicalChina → Hong Kong$0.05500 g99%
AA BLOCKSUnited States$0.05500 g99%
A2B Chem LLCUnited States$0.05500 g99%
ChemsceneUnited States$0.08500 g—
Ambeed, Inc.United States$0.08500 g98%
Fluorochem EUGermany$0.081 kg95%
Fluorochem UKUnited Kingdom$0.081 kg95%
AK Scientific SpecializedUnited States$0.101 kg95%
AK Scientific, Inc.United States$0.131 kg98%
Combi-Blocks, Inc.United States$0.251 kg95%
Angene International LimitedUnited States$0.30500 g97%
Cayman EuropeEstonia$0.37500 g95%
AstaTech, IncUnited States$0.39100 g95%
ALFA AESARGermany$0.48500 g98%
AldlabUnited States$0.5025 g95%
Apollo Scientific UKUnited Kingdom$0.63100 g95%
Sigma-Aldrich (Rush Stock)Germany$0.80500 g101%
Sigma-AldrichGermany$0.80500 g101%
InterbioscreenHong Kong$12.0010 g95%
MolnovaChina$38.001 g99%
TargetMol ChemicalsChina → United States$42.001 g99.92%
MedChemExpress MCESweden$62.921 g99.9%
HTS Biochemie InnovationenGermany$120.0010 g95%
Labotest KGGermany$217.805000 mg90%
Otava, Ltd.Ukraine$2280.0050 mg95%
Otava, Ltd. (2 weeks)Ukraine$2724.0050 mg95%
Princeton BioMolecular Research (SC)United States$2900.00100 mg90%
AngeneChina → Hong Kong$4266.6730 mg99%
Vitas M Chemical LimitedHong Kong$5133.3330 mg90%
AsinexNetherlands$6461.40100 mg90%
Key Organics Ltd.United Kingdom$6900.0010 mg98%
ChemDiv, Inc.United States$12444.449 mg90%
TimTec, LLC (back-ordered)United States$32000.0015 mg94%

Chemical Identity

CAS328-50-7
PubChem CID51
DTXSIDDTXSID5033179
FormulaC5H6O5
Mol. Weight146.1 g/mol
SMILESC(CC(=O)O)C(=O)C(=O)O

Data Sources

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Brief citations

α-ketoglutaric acid (CAS 328-50-7) https://chemicalindependence.com/chemical/328-50-7/ PubChem: 51. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/51 EPA TSCA Inventory: CAS 328-50-7. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 291830 for CAS 328-50-7. Reporting year: 2024. https://usatrade.census.gov/