Propranolol hydrochloride

Drug ingredientActive Shortage

CAS 318-98-9

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

Molecular structure of 318-98-9
1 HCl
US productionNot reported
Import value, 2024$197M
Top sourceChina 36%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292219 · basket

These shares come from HS customs code 292219, which covers 167 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
CN 36%ChinaIT 15%ItalyDE 14%GermanyIN 7%IndiaHU 5%Hungary
48 FDA-registered drug labelers
A-S Medication Solutions
Actavis Pharma, Inc.
Adare Pharmaceuticals Inc
Advanced Rx of Tennessee, LLC
Alivus Life Sciences Limited
American Health Packaging
AMICI PHARMACEUTICALS LLC
Amneal Pharmaceuticals NY LLC
ANI Pharmaceuticals, Inc.
Aphena Pharma Solutions - Tennessee, LLC
Asclemed USA, Inc.
ATLANTIC BIOLOGICALS CORP.
AvKARE
AvPAK
Breckenridge Pharmaceutical, Inc.
Bryant Ranch Prepack
Cardinal Health 107, LLC
COSMA Spa
Coupler LLC
DIRECT RX
Endo USA, Inc.
Fresenius Kabi USA, LLC
Golden State Medical Supply, Inc.
Henry Schein, Inc.
HF Acquisition Co LLC, DBA HealthFirst
Hikma Pharmaceuticals USA Inc.
Ipca Laboratories Limited
Lannett Company, Inc.
Lifestar Pharma LLC
Major Pharmaceuticals
Medical Purchasing Solutions, LLC
Mylan Pharmaceuticals Inc.
NCS HealthCare of KY, LLC dba Vangard Labs
Northwind Health Company, LLC
NuCare Pharmaceuticals,Inc.
PD-Rx Pharmaceuticals, Inc.
Pfizer Ireland Pharmaceuticals Unlimited Company
Pharmaceutical Associates, Inc.
Pierre Fabre Pharmaceuticals, Inc.
Preferred Pharmaceuticals Inc.
Professional Compounding Centers of America
Proficient Rx LP
ProPharma Distribution
REMEDYREPACK INC.
Societa Italiana Medicinali Scandicci S.I.M.S., SrL
Spectrum Laboratory Products, Inc.
ST. MARY'S MEDICAL PARK PHARMACY
W. R. GRACE & CO.-CONN.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 7 drug and cosmetic product listings (FDA).

  • •Propranolol Hydrochloride
  • •InnoPran XL
  • •Inderal XL
  • •Propranolol Hydrochloride ER
  • •Propranolol
  • •Inderal LA
  • •Hemangeol
FDA Shortage Status
Active Shortage
Shortage History
  • Current shortage

    Propranolol Hydrochloride Injection

    Shortage listed since October 31, 2023

    Manufacturer reports: 1 unavailable, 1 available

See all current drug shortages

Vendor Pricing

$0.48/gCombi-Blocks, Inc.
CountryUnited States
Pack$240.00 / 500 g
Purity98%
Vendors26 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

Chemical Identity

CAS318-98-9
PubChem CID62882
DTXSIDDTXSID3021198
FormulaC16H22ClNO2
Mol. Weight295.8 g/mol
SMILESCC(C)NCC(COC1=CC=CC2=CC=CC=C21)O.Cl

Data Sources

Brief citations

Propranolol hydrochloride (CAS 318-98-9) https://chemicalindependence.com/chemical/318-98-9/ PubChem: 62882. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/62882 FDA National Drug Code directory: CAS 318-98-9. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 318-98-9. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 292219 for CAS 318-98-9. Reporting year: 2024. https://usatrade.census.gov/