amantadine sulfate

Drug ingredient

CAS 31377-23-8

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$56M

Top sourceCzech Republic 24%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292130 · basket

These shares come from HS customs code 292130, which covers 39 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CZ 24%Czech RepublicBE 18%BelgiumDE 17%GermanyCN 16%ChinaCA 4%Canada

Portugal
Austria
Latvia
Slovakia
Israel
New Zealand

1 FDA-registered drug labeler

Moehs Cantabra SL

Why It Matters

Sectors

Health

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$1.01/gAaron Chemicals LLC

CountryHong Kong

Pack$505.00 / 500 g

Purity96%

Vendors8 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

7 more vendors

Vendor	Country	$/g	Pack	Purity
Angene Chemical	China → Hong Kong	$1.08	500 g	96%
AA BLOCKS	United States	$1.12	25 g	98%
A2B Chem LLC	United States	$1.83	100 g	98%
Angene International Limited	United States	$17.20	5 g	98%
MedKoo Biosciences, Inc	United States	$18.00	25 g	98%
AstaTech (2 weeks)	United States	$48.00	1 g	95%
Angene	China → Hong Kong	$4266.67	30 mg	96%

Chemical Identity

CAS31377-23-8

PubChem CID124108

DTXSIDDTXSID50953416

FormulaC20H36N2O4S

Mol. Weight400.6 g/mol

SMILESC1C2CC3CC1CC(C2)(C3)N.C1C2CC3CC1CC(C2)(C3)N.OS(=O)(=O)O

Data Sources

PubChem · compound 124108Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

amantadine sulfate (CAS 31377-23-8) https://chemicalindependence.com/chemical/31377-23-8/ PubChem: 124108. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/124108 FDA National Drug Code directory: CAS 31377-23-8. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 292130 for CAS 31377-23-8. Reporting year: 2024. https://usatrade.census.gov/