Estradiol cypionate

Drug ingredient

CAS 313-06-4

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$76M

Top sourceSpain 35%

EPA lists this chemical as inactive, meaning no company reported making, importing or processing it in the US from 2006 to 2016.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293723 · basket

These shares come from HS customs code 293723, which covers 29 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

ES 35%SpainNL 19%NetherlandsCN 18%ChinaIT 16%ItalyHU 4%Hungary

Canada
United Kingdom
Taiwan

13 FDA-registered drug labelers

60592

AX Pharmaceutical Corp

COHESION BIOTEC PRIVATE LIMITED

DARMERICA, LLC

Fagron Inc

LETCO MEDICAL, LLC

MORTAR & PESTLE

Pharmacia & Upjohn Company LLC

SCH Global Services Private Limited

SHAKTI LIFESCIENCE PRIVATE LIMITED

Steroid S.p.A.

Valdepharm

zhejiang xianju pharmaceutical co., Ltd.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Depo-Estradiol

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS313-06-4

PubChem CID9403

DTXSIDDTXSID4022999

FormulaC26H36O3

Mol. Weight396.6 g/mol

SMILESCC12CCC3C(C1CCC2OC(=O)CCC4CCCC4)CCC5=C3C=CC(=C5)O

Data Sources

PubChem · compound 9403Retrieved 2026-04-07
EPA TSCA InventoryRetrieved 2026-04-24
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Estradiol cypionate (CAS 313-06-4) https://chemicalindependence.com/chemical/313-06-4/ PubChem: 9403. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/9403 EPA TSCA Inventory: CAS 313-06-4. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293723 for CAS 313-06-4. Reporting year: 2024. https://usatrade.census.gov/