Chlorambucil

Drug ingredient

CAS 305-03-3

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$503M

Top sourceChina 25%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292249 · basket

These shares come from HS customs code 292249, which covers 170 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 25%ChinaIN 17%IndiaSG 13%SingaporeIT 9%ItalyCH 7%Switzerland

Argentina
Poland
Portugal
Lithuania
Ukraine
Finland
Spain
Egypt
Sweden
Austria
Israel
Latvia
Belgium
Ireland
Mexico
Australia
Peru
Czech Republic
Colombia
Hong Kong

6 FDA-registered drug labelers

AMERICAN PACIFIC CORPORATION

Darmerica

Excella GmbH & Co. KG

Kekule Life Sciences Limited

Sionc Pharmaceutical Private Limited

Waylis Therapeutics LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Leukeran

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$32.92/gAaron Chemicals LLC

CountryHong Kong

Pack$823.00 / 25 g

Purity98%

Vendors22 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

21 more vendors

Vendor	Country	$/g	Pack	Purity
Angene Chemical	China → Hong Kong	$33.12	25 g	98%
A2B Chem LLC	United States	$41.72	25 g	98%
AstaTech (2 weeks)	United States	$52.20	5 g	95%
AA BLOCKS	United States	$54.76	25 g	98%
Apexbio Technology LLC	United States	$58.40	10 g	97.86%
Ambeed, Inc.	United States	$60.24	25 g	98%
Angene International Limited	United States	$95.00	1 g	97%
Biopharma PEG Scientific Inc.	United States	$110.00	1 g	95%
Sigma-Aldrich (Rush Stock)	Germany	$118.02	10 g	—
Sigma-Aldrich	Germany	$118.02	10 g	—
Cayman Europe	Estonia	$128.52	1 g	98%
MedChemExpress MCE	Sweden	$150.04	5 g	99.84%
Fulfilled by Molport	Latvia	$160.00	50 mg	98%
TargetMol Chemicals	China → United States	$326.00	500 mg	99.58%
Labotest KG	Germany	$453.00	1000 mg	90%
MedKoo Biosciences, Inc	United States	$525.00	2 g	98%
Molnova	China	$650.00	200 mg	99%
TargetMol Chemicals EU	Austria	$810.00	100 mg	99.58%
Angene	China → Hong Kong	$4266.67	30 mg	98%
Key Organics Ltd.	United Kingdom	$6900.00	10 mg	95%
TimTec, LLC	United States	$9333.33	30 mg	90%

Chemical Identity

CAS305-03-3

PubChem CID2708

DTXSIDDTXSID7020263

FormulaC14H19Cl2NO2

Mol. Weight304.2 g/mol

SMILESC1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl

Data Sources

PubChem · compound 2708Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Chlorambucil (CAS 305-03-3) https://chemicalindependence.com/chemical/305-03-3/ PubChem: 2708. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/2708 FDA National Drug Code directory: CAS 305-03-3. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 292249 for CAS 305-03-3. Reporting year: 2024. https://usatrade.census.gov/