Potassium D-gluconate

Drug ingredient

CAS 299-27-4

This drug ingredient has classified U.S. production volumes. EPA withholds the number as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$16M

Top sourceItaly 41%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291816 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 291816, which covers 9 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IT 41%ItalyCN 32%ChinaIN 17%IndiaDE 6%GermanyTR 2%Turkey

Israel
Pakistan
Japan

EPA-registered manufacturers (3)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Basf Se · DE Germany

Basf

Macdermid

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Henkel

Why It Matters

Sectors

HealthMetals & MiningCore Chemicals

Downstream Uses

Appears in 12 drug and cosmetic product listings (FDA).

•Cardiotone
•Allergen II
•Electrolyte Plus
•GI Drainage
•Enviro I
•Allergen I
•Spleenex V
•Systemic Drainage

Show all 12

•Bio Electrolyte
•Recovatone
•E.O.L.
•SAMe Liquescence 3036

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 2 sectors as 4 functional roles.

•Chelating agent in All Other Chemical Product and Preparation ManufacturingProcessing—incorporation into formulation, mixture, or reaction product
•Plating agent in All Other Chemical Product and Preparation ManufacturingProcessing—incorporation into formulation, mixture, or reaction product
•Etching agent in All Other Chemical Product and Preparation ManufacturingProcessing—incorporation into formulation, mixture, or reaction product
•Cleaning agent in Fabricated Metal Product ManufacturingUse—non-incorporative activities

Chemical Identity

CAS299-27-4

PubChem CID16760467

DTXSIDDTXSID7029617

FormulaC6H11KO7

Mol. Weight234.25 g/mol

SMILESC(C(C(C(C(C(=O)[O-])O)O)O)O)O.[K+]

Data Sources

EPA CompTox (DSSTox) · DTXSID7029617Retrieved 2026-04-06
PubChem · compound 16760467Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Potassium D-gluconate (CAS 299-27-4) https://chemicalindependence.com/chemical/299-27-4/ EPA CompTox (DSSTox): DTXSID7029617. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID7029617 PubChem: 16760467. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/16760467 EPA Chemical Data Reporting: 299-27-4. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 299-27-4. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 291816 for CAS 299-27-4. Reporting year: 2024. https://usatrade.census.gov/