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Methylphenidate hydrochloride

Drug ingredientActive Shortage

CAS 298-59-9

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

Molecular structure of 298-59-9
1 HCl
US productionNot reported
Import value, 2024$2M
Top sourceSwitzerland 86%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293333 · basket

These shares come from HS customs code 293333, which covers 11 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
CH 86%SwitzerlandCN 11%ChinaIT 1%ItalyUA 1%Ukraine
55 FDA-registered drug labelers
Accord Healthcare, Inc.
Actavis Pharma, Inc.
American Health Packaging
Amneal Pharmaceuticals of New York LLC
Ascend Laboratories, LLC
Aurolife Pharma, LLC
AvPAK
Aytu BioPharma, Inc.
Bryant Ranch Prepack
Camber Pharmaceutical Inc
Camber Pharmaceuticals Inc.
Cambrex Charles City, Inc
Catalent Pharma Solutions, LLC
Chattem Chemicals, Inc.
Cranbury Pharmaceuticals, LLC
Curia Missouri, Inc.
Dr. Reddy's Laboratories Inc
Eywa Pharma Inc
Golden State Medical Supply, Inc.
Granules Pharmaceuticals Inc.
Ironshore Pharmaceuticals Inc.
Janssen Pharmaceutical Sciences Unlimited Company
Janssen Pharmaceuticals, Inc.
KVK-TECH, INC.
Lannett Company, Inc.
Lupin Pharmaceuticals,Inc.
Mayne Pharma
Medisca Inc.
Neolpharma, Inc.
NextWave Pharmaceuticals, Inc
Nivagen Pharmaceuticals, Inc.
Noramco, LLC
Northstar Rx LLC
Novartis Pharmaceuticals Corporation
Patrin Pharma, Inc.
Professional Compounding Center of America
Professional Compounding Centers of America
QUAGEN PHARMACEUTICALS LLC
Rhodes Pharmaceuticals
Rhodes Pharmaceuticals L.P.
Rising Pharma Holdings, Inc.
S&B Pharma LLC dba Norac Pharma
Sandoz Inc
SHIONOGI INC.
Siegfried USA, LLC
Societal CDMO Gainesville, LLC
Solco Healthcare US,LLC
SpecGx LLC
Spectrum Laboratory Products, Inc.
Sun Pharmaceutical Industries, Inc.
Teva Pharmaceuticals USA, Inc.
Trigen Laboratories, LLC
Veranova, L.P.
Vertical Pharmaceuticals, LLC
XLCare Pharmaceuticals Inc

Why It Matters

Sectors
Health
Downstream Uses

Appears in 16 drug and cosmetic product listings (FDA).

  • •Methylphenidate Hydrochloride
  • •Methylphenidate
  • •Concerta
  • •Relexxii
  • •Methylphenidate Hydrochloride Extended-Release
  • •Jornay PM Extended-Release
  • •Methylphenidate Hydrochloride (LA)
  • •QuilliChew ER
Show all 16
  • •Aptensio XR
  • •Metadate CD
  • •methylphenidate hydrochloride CD
  • •Ritalin
  • •Quillivant XR
  • •Ritalin LA
  • •Methylphenidate HCl
  • •Methylin
FDA Shortage Status
Active Shortage
Shortage History
  • Current shortage

    Methylphenidate Hydrochloride Tablet, Extended Release

    Shortage listed since July 26, 2023

    Manufacturer reports: 1 unavailable, 1 limited, 1 available

See all current drug shortages

Chemical Identity

CAS298-59-9
PubChem CID9280
DTXSIDDTXSID8020886
FormulaC14H20ClNO2
Mol. Weight269.77 g/mol
SMILESCOC(=O)C(C1CCCCN1)C2=CC=CC=C2.Cl

Data Sources

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Brief citations

Methylphenidate hydrochloride (CAS 298-59-9) https://chemicalindependence.com/chemical/298-59-9/ PubChem: 9280. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/9280 FDA National Drug Code directory: CAS 298-59-9. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 298-59-9. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293333 for CAS 298-59-9. Reporting year: 2024. https://usatrade.census.gov/