methylprednisolone hemisuccinate

Drug ingredient

CAS 2921-57-5

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$154M

Top sourceItaly 60%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293729 · basket

These shares come from HS customs code 293729, which covers 57 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IT 60%ItalyES 14%SpainCN 11%ChinaDE 6%GermanyAT 2%Austria

Netherlands
Australia
Malaysia
Portugal
United Kingdom
Japan
Malta
Canada
Israel
Singapore
New Zealand
Poland
Ukraine
Belgium
Sweden

7 FDA-registered drug labelers

EUROAPI FRANCE

Hubei Gedian humanwell Pharmaceutical Co., Ltd

NEWCHEM SPA

Pharmacia & Upjohn Company LLC

Symbiotec Pharmalab Limited

SYMBIOTICA SPECIALITY INGREDIENTS SDN.BHD

Tianjin Tianyao Pharmaceuticals Co., Ltd.

Why It Matters

Sectors

Health

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS2921-57-5

PubChem CID16923

DTXSIDDTXSID80183466

FormulaC26H34O8

Mol. Weight474.5 g/mol

SMILESCC1CC2C3CCC(C3(CC(C2C4(C1=CC(=O)C=C4)C)O)C)(C(=O)COC(=O)CCC(=O)O)O

Data Sources

PubChem · compound 16923Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

methylprednisolone hemisuccinate (CAS 2921-57-5) https://chemicalindependence.com/chemical/2921-57-5/ PubChem: 16923. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/16923 FDA National Drug Code directory: CAS 2921-57-5. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293729 for CAS 2921-57-5. Reporting year: 2024. https://usatrade.census.gov/