Guanfacine hydrochloride

Drug ingredient

CAS 29110-48-3

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 29110-48-3 — 1 HCl

US productionNot reported

Top sourceNo public record

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Where It Comes From

EPA and Census publish no US supply data for this chemical.

43 FDA-registered drug labelers

A-S Medication Solutions

A2A Integrated Pharmaceuticals

Actavis Pharma, Inc.

Advagen Pharma Limited

Advagen Pharma Ltd

Ajanta Pharma USA Inc.

Alembic Pharmaceuticals Inc.

Alembic Pharmaceuticals Limited

Amneal Pharmaceuticals LLC

Amneal Pharmaceuticals of New York LLC

Apotex Corp.

Aurobindo Pharma Limited

AvKARE

AvPAK

Bryant Ranch Prepack

Chartwell RX, LLC

Coupler LLC

Direct_Rx

Epic Pharma, LLC

Fosun Pharma USA, Inc

Golden State Medical Supply, Inc.

i3 Pharmaceuticals, LLC

Industriale Chimica s.r.l.

Jubilant Biosys limited

Major Pharmaceuticals

Medichem S.A.

NORTHSTAR RX LLC

Patheon Manufacturing Services LLC

PharmaZell GmbH

Precision Dose, Inc.

PROCOS S.p.A.

Proficient Rx LP

PuraCap Laboratories LLC dba Blu Pharmaceuticals

Quimica Sintetica S.A.

REMEDYREPACK INC.

Slate Run Pharmaceuticals, LLC

ST. MARY'S MEDICAL PARK PHARMACY

Sun Pharmaceutical Industries, Inc

Takeda Pharmaceuticals America, Inc.

TWi Pharmaceuticals, Inc.

Unichem Laboratories Limited, India

Unichem Pharmaceuticals (USA), Inc.

XIROMED, LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 5 drug and cosmetic product listings (FDA).

•Guanfacine
•Guanfacine Hydrochloride
•Guanfacine extended-release
•Intuniv
•Guanfacine ER

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

to be discontinued
Guanfacine Hydrochloride Tablet, Extended Release
Shortage listed since November 13, 2025

See all current drug shortages

Chemical Identity

CAS29110-48-3

PubChem CID71401

DTXSIDDTXSID2045157

FormulaC9H10Cl3N3O

Mol. Weight282.5 g/mol

SMILESC1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl.Cl

Data Sources

PubChem · compound 71401Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04

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Brief citations

Guanfacine hydrochloride (CAS 29110-48-3) https://chemicalindependence.com/chemical/29110-48-3/ PubChem: 71401. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/71401 FDA National Drug Code directory: CAS 29110-48-3. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 29110-48-3. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/