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Alprazolam

Drug ingredient

CAS 28981-97-7

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 28981-97-7
US productionNot reported
Import value, 2024$10M
Top sourceItaly 73%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293391 · basket

These shares come from HS customs code 293391, which covers 14 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IT 73%ItalyIN 21%IndiaIL 4%IsraelFI 1%Finland
37 FDA-registered drug labelers
A-S Medication Solutions
Actavis Pharma, Inc.
Advanced Rx of Tennessee, LLC
Advanced Rx Pharmacy of Tennessee, LLC
American Health Packaging
Amneal Pharmaceuticals LLC
ANI Pharmaceuticals, Inc.
Aphena Pharma Solutions - Tennessee, LLC
Asclemed USA, Inc.
Aurobindo Pharma Limited
AvPAK
Bryant Ranch Prepack
Cambrex Profarmaco Milano Srl
Centaur Pharmaceuticals Private Limited
Direct_Rx
Fermion Oy
Hikma Pharmaceuticals USA Inc.
Malladi Drugs & Pharmaceuticals Limited
Matrix Pharmacorp Private Limited
Medsource Pharmaceuticals
Mylan Pharmaceuticals Inc.
Natco Pharma USA LLC
Northwind Health Company, LLC
NuCare Pharmaceuticals, Inc.
Par Health USA, LLC
PD-Rx Pharmaceuticals, Inc.
Pfizer Ireland Pharmaceuticals Unlimited Company
PHARMACIA & UPJOHN COMPANY LLC
Pharmacia and Upjohn Company LLC
Preferred Pharmaceuticals Inc.
Proficient Rx LP
Quality Care Products, LLC
R.L.Fine Chem Private Limited
REMEDYREPACK INC.
Sandoz Inc
ST. MARY'S MEDICAL PARK PHARMACY
Viatris Specialty LLC

Why It Matters

Sectors
Health
Downstream Uses

Appears in 7 drug and cosmetic product listings (FDA).

  • •Alprazolam
  • •Alprazolam C-IV
  • •Alprazolam XR
  • •Alprazolam Extended Release
  • •Xanax
  • •Alprazolam ODT C-IV
  • •Xanax XR
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS28981-97-7
PubChem CID2118
DTXSIDDTXSID4022577
FormulaC17H13ClN4
Mol. Weight308.8 g/mol
SMILESCC1=NN=C2N1C3=C(C=C(C=C3)Cl)C(=NC2)C4=CC=CC=C4

Data Sources

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Brief citations

Alprazolam (CAS 28981-97-7) https://chemicalindependence.com/chemical/28981-97-7/ PubChem: 2118. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/2118 FDA National Drug Code directory: CAS 28981-97-7. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293391 for CAS 28981-97-7. Reporting year: 2024. https://usatrade.census.gov/