Sorafenib

Drug ingredient

CAS 284461-73-0

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$1.3B

Top sourceChina 32%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293339 · basket

These shares come from HS customs code 293339, which covers 397 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 32%ChinaIN 15%IndiaDE 10%GermanyBE 9%BelgiumCH 8%Switzerland

Taiwan
Ukraine
Sweden
Argentina
Canada
Finland
Malta
Israel
Netherlands
Denmark
United Arab Emirates
Mexico
Brunei
Slovakia
Australia
South Africa
Poland
Latvia
Lithuania
Estonia
Slovenia
Czech Republic
Croatia
Hong Kong

8 FDA-registered drug labelers

Bayer AG

Bayer HealthCare Pharmaceuticals Inc.

Golden State Medical Supply, Inc.

MSN Laboratories Private Limited

Patheon France S.A.S

Torrent Pharmaceuticals Limited

Upsher-Smith Laboratories, LLC

Yabao Pharmaceutical Co., Ltd. Beijing

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•sorafenib
•Nexavar

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$1.76/gAaron Chemicals LLC

CountryHong Kong

Pack$176.00 / 100 g

Purity99%

Vendors24 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

23 more vendors

Vendor	Country	$/g	Pack	Purity
Angene Chemical	China → Hong Kong	$1.89	100 g	99%
A2B Chem LLC	United States	$2.15	100 g	99%
AstaTech, Inc	United States	$2.57	100 g	97%
AK Scientific Specialized	United States	$2.60	100 g	95%
Combi-Blocks, Inc.	United States	$2.60	100 g	98%
AA BLOCKS	United States	$2.80	100 g	99%
Ambeed, Inc.	United States	$2.87	100 g	99%
AK Scientific, Inc.	United States	$3.57	100 g	98%
Apollo Scientific UK	United Kingdom	$39.60	5 g	98%
MedKoo Biosciences, Inc	United States	$82.50	20 g	98%
TargetMol Chemicals	China → United States	$91.00	1 g	99.89%
Apexbio Technology LLC	United States	$110.00	1 g	99.87%
Molnova	China	$116.00	500 mg	99%
TargetMol Chemicals EU	Austria	$126.00	500 mg	99.89%
MedChemExpress MCE	Sweden	$157.30	1 g	99.9%
Angene International Limited	United States	$406.00	500 mg	99%
ChemFaces	China	$1500.00	20 mg	98%
Axon Medchem	Netherlands	$2880.00	50 mg	99%
Angene	China → Hong Kong	$4266.67	30 mg	99%
Cayman Europe	Estonia	$5807.20	50 mg	98%
Key Organics Ltd.	United Kingdom	$11700.00	10 mg	97%
Asinex	Netherlands	$12922.80	100 mg	90%
TimTec, LLC (back-ordered)	United States	$32000.00	15 mg	94%

Chemical Identity

CAS284461-73-0

PubChem CID216239

DTXSIDDTXSID7041128

FormulaC21H16ClF3N4O3

Mol. Weight464.8 g/mol

SMILESCNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

Data Sources

PubChem · compound 216239Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Sorafenib (CAS 284461-73-0) https://chemicalindependence.com/chemical/284461-73-0/ PubChem: 216239. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/216239 FDA National Drug Code directory: CAS 284461-73-0. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293339 for CAS 284461-73-0. Reporting year: 2024. https://usatrade.census.gov/