Bumetanide

Drug ingredientActive Shortage

CAS 28395-03-1

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

Molecular structure of 28395-03-1
US productionNot reported
Import value, 2024$2.0B
Top sourceIreland 63%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293590 · basket

These shares come from HS customs code 293590, which covers 182 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IE 63%IrelandSG 14%SingaporeIN 7%IndiaCN 7%ChinaCH 2%Switzerland
47 FDA-registered drug labelers
A-S Medication Solutions
Advagen Pharma Limited
allphamed Pharbil Arzneimittel GmbH
American Health Packaging
Amneal Pharmaceuticals NY LLC
Anthea Pharma Private Limited
Aphena Pharma Solutions - Tennessee, LLC
AvPAK
Bryant Ranch Prepack
Camber Pharmaceuticals, Inc.
Cardinal Health 107, LLC
Civica, Inc.
Corstasis USA LLC
Edenbridge Pharmaceuticals LLC.
Exelan Pharmaceuticals, Inc.
First Nation Group, LLC
Fresenius Kabi USA, LLC
Gland Pharma Limited
GLENMARK PHARMACEUTICALS INC., USA
Guilin Pharmaceutical Co., Ltd.
Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.
HF Acquisition Co LLC, DBA HealthFirst
Hikma Pharmaceuticals USA Inc.
Industriale Chimica s.r.l.
Lifestar Pharma LLC
Lupin Pharmaceuticals, Inc.
Major Pharmaceuticals
Medilux Laboratories Private Limited
MSN Laboratories Private Limited
Mullan Pharmaceutical Inc.
NCS HealthCare of KY, LLC dba Vangard Labs
NorthStar Rx, LLC
Novadoz Pharmaceuticals LLC
Olon SpA
Proficient Rx LP
Qilu Pharmaceutical Co., Ltd.
REMEDYREPACK INC.
Rising Pharma Holdings, Inc
Sagent Pharmaceuticals
Sandoz Inc
Solara Active Pharma Sciences Limited
Solco Healthcare LLC
Sun Pharmaceutical Industries, Inc.
Upsher-Smith Laboratories, LLC
Validus Pharmaceuticals LLC
Zydus Lifesciences Limited
Zydus Pharmaceuticals (USA) Inc.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

  • •Bumetanide
  • •Enbumyst
  • •Bumex
FDA Shortage Status
Active Shortage
Shortage History
  • Current shortage

    Bumetanide Injection

    Shortage listed since December 13, 2017

    Manufacturer reports: 2 limited, 2 available

  • to be discontinued

    Bumetanide Tablet

    Shortage listed since May 2, 2025

See all current drug shortages

Vendor Pricing

$30.90/gAK Scientific Specialized
CountryUnited States
Pack$309.00 / 10 g
Purity95%
Vendors15 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

Chemical Identity

CAS28395-03-1
PubChem CID2471
DTXSIDDTXSID5022699
FormulaC17H20N2O5S
Mol. Weight364.4 g/mol
SMILESCCCCNC1=C(C(=CC(=C1)C(=O)O)S(=O)(=O)N)OC2=CC=CC=C2

Data Sources

Brief citations

Bumetanide (CAS 28395-03-1) https://chemicalindependence.com/chemical/28395-03-1/ PubChem: 2471. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/2471 FDA National Drug Code directory: CAS 28395-03-1. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 28395-03-1. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293590 for CAS 28395-03-1. Reporting year: 2024. https://usatrade.census.gov/