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timolol maleate

Drug ingredient

CAS 26921-17-5

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 26921-17-5
US productionNot reported
Import value, 2024$6.4B
Top sourceSingapore 36%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293499 · basket

These shares come from HS customs code 293499, which covers 575 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
SG 36%SingaporeIE 23%IrelandCN 11%ChinaCH 6%SwitzerlandIN 5%India
48 FDA-registered drug labelers
A-S Medication Solutions
Akorn
Alembic Pharmaceuticals Inc.
Alembic Pharmaceuticals Limited
Allergan, Inc.
Apotex Corp.
ARMAS PHARMACEUTICALS INC
Aurobindo Pharma Limited
AX Pharmaceutical Corp
Bausch & Lomb Americas Inc.
Bausch & Lomb Incorporated
Bryant Ranch Prepack
C-SQUARED PHARMA LIMITED
Caplin Steriles Limited
Centaur Pharmaceuticals Private Limited
Dr. Reddy's Laboratories, Inc.
Excella GmbH & Co. KG
FAREVA LA VALLEE
FDC Limited
First Nation Group, LLC
Florida Pharmaceutical Products, LLC
FOSUN PHARMA USA INC
Genus Lifesciences
Gland Pharma Limited
Glenmark Pharmaceuticals Inc., USA
Haleos Labs Limited
Indoco Remedies Limited
Ingenus Pharmaceuticals, LLC
Leading Pharma, LLC
Lifestar Pharma LLC
Medisca Inc.
Micro Labs Limited
Mylan Pharmaceuticals Inc.
Nordic Pharma, Inc.
NorthStar RxLLC
Oceanside Pharmaceuticals
Olon SpA
Pacific Pharma, Inc.
PCAS FINLAND OY
Rising Pharma Holdings, Inc.
Sagent Pharmaceuticals
Sandoz Inc
Somerset Therapeutics, LLC
Spectrum Laboratory Products, Inc.
Syn-Tech Chem. & Pharm. Co., Ltd.
TAPI Croatia Industries Ltd.
Thea Pharma Inc.
Upsher-Smith Laboratories, LLC

Why It Matters

Sectors
Health
Downstream Uses

Appears in 22 drug and cosmetic product listings (FDA).

  • •Dorzolamide Hydrochloride and Timolol Maleate
  • •Timolol maleate
  • •Timolol Maleate Ophthalmic Gel Forming Solution 0.5%
  • •Dorzolamide Hydrochloride and Timolol Maleate Ophthalmic Solution
  • •Timolol GFS
  • •Brimonidine Tartrate and Timolol Maleate
  • •Dorzolamide and Timolol
  • •Timolol hemihydrate
Show all 22
  • •Brimonidine Tartrate/Timolol Maleate
  • •Timoptic-XE
  • •Timolol Maleate Ophthalmic Gel Forming Solution, 0.25%
  • •Brimonidine Tartrate/Timolol Maleate Ophthalmic Solution
  • •Timoptic
  • •Dorzolamide Hydrochloride and Timolol Maleate Preservative Free
  • •Dorzolamide Hydrochloride Timolol Maletae
  • •Timoptic in Ocudose
  • •timolol maleate ophthalmic gel forming solution
  • •Cosopt
  • •Istalol
  • •Cosopt PF
  • •Combigan
  • •Dorzolamide Hydrochloride Timolol Maleate
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS26921-17-5
PubChem CID5281056
DTXSIDDTXSID3047504
FormulaC17H28N4O7S
Mol. Weight432.5 g/mol
SMILESCC(C)(C)NCC(COC1=NSN=C1N2CCOCC2)O.C(=CC(=O)O)C(=O)O

Data Sources

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Brief citations

timolol maleate (CAS 26921-17-5) https://chemicalindependence.com/chemical/26921-17-5/ PubChem: 5281056. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5281056 FDA National Drug Code directory: CAS 26921-17-5. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293499 for CAS 26921-17-5. Reporting year: 2024. https://usatrade.census.gov/