Fosaprepitant dimeglumine

Drug ingredient

CAS 265121-04-8

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$6.4B

Top sourceSingapore 36%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293499 · basket

These shares come from HS customs code 293499, which covers 575 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

SG 36%SingaporeIE 23%IrelandCN 11%ChinaCH 6%SwitzerlandIN 5%India

Finland
Netherlands
Canada
Indonesia
Mexico
Taiwan
South Korea
Austria
Croatia
Sweden
Ukraine
Denmark
Israel
Czech Republic
New Zealand
Hong Kong
Kyrgyzstan
Australia
Portugal
South Africa
Poland
Slovenia
Brazil
Slovakia
Vietnam
Latvia
Malta
Hungary
Romania
Kenya
Belarus
Russia
Turkey
Norway

32 FDA-registered drug labelers

Actavis Pharma, Inc.

Alivus Life Sciences Limited

Amneal Pharmaceuticals LLC

Apothecon Pharmaceuticals Pvt Ltd

Aurobindo Pharma Limited

Avenacy, LLC

Baxter Healthcare Corporation

BE Pharmaceuticals Inc.

BluePoint Laboratories

Camber Pharmaceuticals, Inc.

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Dr. Reddy's Laboratories Inc.,

Dr. Reddy's Laboratories Limited

Eugia US LLC

F.I.S. Fabbrica Italiana Sintetici S.P.A.

FAREVA LA VALLEE

Fresenius Kabi USA, LLC

Hetero Drugs Limited

Hikma Pharmaceuticals USA Inc.

Lianyungang Runzhong Pharmaceutical Co., Ltd.

MAHI DRUGS PRIVATE LIMITED

Merck Sharp & Dohme LLC

MSN Laboratories Private Limited

Mylan Institutional LLC

NorthStar RxLLC

Novadoz Pharmaceuticals LLC

Patheon Manufacturing Services LLC

Piramal Pharma Limited

Qilu Pharmaceutical Co., Ltd.

ScinoPharm Taiwan Ltd.

Steriscience Specialties Private Limited

Wisdom Pharmaceutical Co.,Ltd

Why It Matters

Sectors

Health

Downstream Uses

Appears in 4 drug and cosmetic product listings (FDA).

•Fosaprepitant
•Focinvez
•Fosaprepitant Dimeglumine
•Emend

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

to be discontinued
Fosaprepitant Dimeglumine Injection
Shortage listed since April 8, 2026

See all current drug shortages

Chemical Identity

CAS265121-04-8

PubChem CID135564864

DTXSIDDTXSID50181095

FormulaC37H56F7N6O16P

Mol. Weight1004.8 g/mol

SMILESCC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NN(C(=O)N3)P(=O)(O)O)C4=CC=C(C=C4)F.CNCC(C(C(C(CO)O)O)O)O.CNCC(C(C(C(CO)O)O)O)O

Data Sources

PubChem · compound 135564864Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Fosaprepitant dimeglumine (CAS 265121-04-8) https://chemicalindependence.com/chemical/265121-04-8/ PubChem: 135564864. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/135564864 FDA National Drug Code directory: CAS 265121-04-8. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 265121-04-8. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293499 for CAS 265121-04-8. Reporting year: 2024. https://usatrade.census.gov/