Toluenediamine

CAS 25376-45-8

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$132M

Top sourceChina 27%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292151 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 292151, which covers 51 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 27%ChinaBE 26%BelgiumKR 17%South KoreaDE 16%GermanyIN 13%India

United Kingdom
Slovakia
Argentina
Brazil
Poland
Spain
Netherlands
Taiwan
Japan

EPA-registered manufacturers (3)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Basf Se · DE Germany

Basf

Covestro

EPA-registered importers (1)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Dow Chemical

Why It Matters

Sectors

WaterPlastics & RubberTextilesCore Chemicals

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 4 sectors as 3 functional roles.

•Intermediate in Synthetic Dye and Pigment Manufacturing (15%)Processing as a reactant
•Corrosion inhibitor in Utilities (12%)Processing as a reactant
•Monomers in All Other Basic Organic Chemical Manufacturing (73%)Processing as a reactant
•Intermediate in All Other Basic Organic Chemical ManufacturingProcessing as a reactant
•Intermediate in Plastics Material and Resin Manufacturing (100%)Processing as a reactant

Chemical Identity

CAS25376-45-8

PubChem CIDNot recorded

DTXSIDDTXSID9027869

FormulaNot recorded

Mol. WeightNot recorded

SMILESNot recorded

Data Sources

EPA CompTox (DSSTox) · DTXSID9027869Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Toluenediamine (CAS 25376-45-8) https://chemicalindependence.com/chemical/25376-45-8/ EPA CompTox (DSSTox): DTXSID9027869. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID9027869 EPA Chemical Data Reporting: 25376-45-8. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 25376-45-8. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 292151 for CAS 25376-45-8. Reporting year: 2024. https://usatrade.census.gov/