2,2'-Methylenedi(phenyl isocyanate)

CAS 2536-05-2

EPA’s 2023 records show zero U.S. production of this chemical.

US productionZero

Import value, 2024$171M

Import volumeCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Top sourceHungary 35%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292910 · basket

EPA reports by year

2023: US production Zero · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 292910, which covers 57 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

HU 35%HungaryDE 20%GermanyIT 15%ItalyCN 8%ChinaES 7%Spain

Mexico
India
Switzerland
Panama
United Kingdom
Egypt
Ukraine
Poland
Finland
Malaysia
Slovakia
Austria

EPA-registered importers (2)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Basf Se · DE Germany

Basf

Why It Matters

Sectors

Metals & MiningPlastics & RubberPaints & Coatings

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 3 sectors as 2 functional roles.

•Monomers in Miscellaneous ManufacturingProcessing as a reactant
•Monomers in Plastics Material and Resin ManufacturingProcessing as a reactant
•Paint additives and coating additives not described by other categories in Paint and Coating Manufacturing (29%)Use—non-incorporative activities

Vendor Pricing

$3028.00/gAstaTech, Inc

CountryUnited States

Pack$757.00 / 250 mg

Purity95%

Vendors5 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

4 more vendors

Vendor	Country	$/g	Pack	Purity
A2B Chem LLC	United States	$3080.00	250 mg	95%
AA BLOCKS	United States	$3412.00	250 mg	95%
Angene International Limited	United States	$4856.00	250 mg	95%
Aaron Chemicals LLC	Hong Kong	$10400.00	250 mg	—

Chemical Identity

CAS2536-05-2

PubChem CID62450

DTXSIDDTXSID90883107

FormulaC15H10N2O2

Mol. Weight250.25 g/mol

SMILESC1=CC=C(C(=C1)CC2=CC=CC=C2N=C=O)N=C=O

Data Sources

EPA CompTox (DSSTox) · DTXSID90883107Retrieved 2026-04-06
PubChem · compound 62450Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2019 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

2,2'-Methylenedi(phenyl isocyanate) (CAS 2536-05-2) https://chemicalindependence.com/chemical/2536-05-2/ EPA CompTox (DSSTox): DTXSID90883107. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID90883107 PubChem: 62450. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/62450 EPA Chemical Data Reporting: 2536-05-2. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 2536-05-2. Reporting year: 2019. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 292910 for CAS 2536-05-2. Reporting year: 2024. https://usatrade.census.gov/