Amphetamine aspartate

Drug ingredientActive Shortage

CAS 25333-81-7

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

US productionNot reported

Import value, 2024$503M

Top sourceChina 25%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292249 · basket

These shares come from HS customs code 292249, which covers 170 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 25%ChinaIN 17%IndiaSG 13%SingaporeIT 9%ItalyCH 7%Switzerland

Argentina
Poland
Portugal
Lithuania
Ukraine
Finland
Spain
Egypt
Sweden
Austria
Israel
Latvia
Belgium
Ireland
Mexico
Australia
Peru
Czech Republic
Colombia
Hong Kong

7 FDA-registered drug labelers

Bryant Ranch Prepack

Cambrex Charles City, Inc

Neolpharma, Inc.

Northstar Rx LLC

SpecGx LLC

Sun Pharmaceutical Industries, Inc.

Veranova, L.P.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Dextroamphetamine saccharate, amphetamine aspartate, dextroamphetamine sulfate, and amphetamine sulfate
•Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, Amphetamine Sulfate

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

Active Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

Current shortage
Amphetamine Aspartate Monohydrate, Amphetamine Sulfate, Dextroamphetamine Saccharate, Dextroamphetamine Sulfate Tablet
Shortage listed since October 12, 2022
Manufacturer reports: 1 unavailable, 3 limited, 2 available

See all current drug shortages

Chemical Identity

CAS25333-81-7

PubChem CID9801310

DTXSIDDTXSID80948178

FormulaC22H33N3O4

Mol. Weight403.5 g/mol

SMILESCC(CC1=CC=CC=C1)N.CC(CC1=CC=CC=C1)N.C(C(C(=O)O)N)C(=O)O

Data Sources

PubChem · compound 9801310Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Amphetamine aspartate (CAS 25333-81-7) https://chemicalindependence.com/chemical/25333-81-7/ PubChem: 9801310. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/9801310 FDA National Drug Code directory: CAS 25333-81-7. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 25333-81-7. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 292249 for CAS 25333-81-7. Reporting year: 2024. https://usatrade.census.gov/