Phosphoric acid, trihexyl ester

CAS 2528-39-4

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$123M

Top sourceChina 66%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291990 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 291990, which covers 77 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 66%ChinaDE 18%GermanyJP 5%JapanIN 3%IndiaCH 3%Switzerland

Poland
Canada
Taiwan
Belgium
Netherlands
Malaysia
Austria
Spain
Ireland
Mexico
South Korea
Turkey
Czech Republic
Hong Kong

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Fujifilm Holdings America

Why It Matters

Sectors

Consumer Products

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Solvent in Photographic Film, Paper, Plate, and Chemical Manufacturing (100%)Processing—incorporation into article

Vendor Pricing

$7.40/gA2B Chem LLC

CountryUnited States

Pack$185.00 / 25 g

Purity90%

Vendors11 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

10 more vendors

Vendor	Country	$/g	Pack	Purity
Combi-Blocks, Inc.	United States	$7.40	25 g	90%
Aaron Chemicals LLC	Hong Kong	$7.84	25 g	95%
BLD Pharmatech Ltd.	China	$8.40	25 g	98%
Angene Chemical	China → Hong Kong	$8.44	25 g	95%
AA BLOCKS	United States	$9.60	25 g	90%
BLD Pharmatech GmbH	Germany	$12.00	5 g	98%
ALFA AESAR	Germany	$20.16	25 g	90%
AstaTech (2 weeks)	United States	$58.00	1 g	95%
MedChemExpress MCE	Sweden	$1246.30	100 mg	99%
Angene	China → Hong Kong	$4266.67	30 mg	95%

Chemical Identity

CAS2528-39-4

PubChem CID75666

DTXSIDDTXSID1074597

FormulaC18H39O4P

Mol. Weight350.5 g/mol

SMILESCCCCCCOP(=O)(OCCCCCC)OCCCCCC

Data Sources

EPA CompTox (DSSTox) · DTXSID1074597Retrieved 2026-04-06
PubChem · compound 75666Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2019 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Phosphoric acid, trihexyl ester (CAS 2528-39-4) https://chemicalindependence.com/chemical/2528-39-4/ EPA CompTox (DSSTox): DTXSID1074597. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID1074597 PubChem: 75666. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/75666 EPA Chemical Data Reporting: 2528-39-4. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 2528-39-4. Reporting year: 2019. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 291990 for CAS 2528-39-4. Reporting year: 2024. https://usatrade.census.gov/