2,4,6,8-Tetramethylcyclotetrasiloxane

CAS 2370-88-9

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$537M

Top sourceChina 39%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293190 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 293190, which covers 378 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 39%ChinaDE 17%GermanyIT 9%ItalyIN 7%IndiaJP 7%Japan

Ireland
Netherlands
Switzerland
Monaco
Ukraine
Spain
Mexico
Poland
Indonesia
Armenia
Israel
Sweden
Australia
Czech Republic
Hungary
Brunei
Hong Kong
Brazil
Thailand
Argentina
Finland
Austria
Latvia

EPA-registered importers (1)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Dow Chemical

Why It Matters

Sectors

Core Chemicals

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Intermediate in All Other Basic Inorganic Chemical Manufacturing (100%)Processing as a reactant

Vendor Pricing

$0.15/gAaron Chemicals LLC

CountryHong Kong

Pack$74.00 / 500 g

PurityNot recorded

Vendors11 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

10 more vendors

Vendor	Country	$/g	Pack	Purity
Angene Chemical	China → Hong Kong	$0.15	500 g	98%
Fluorochem UK	United Kingdom	$0.57	25 g	95%
A2B Chem LLC	United States	$0.61	500 g	98%
Chemscene	United States	$0.80	100 g	—
AA BLOCKS	United States	$0.80	500 g	98%
Combi-Blocks, Inc.	United States	$0.81	500 g	95%
MedChemExpress MCE	Sweden	$1.00	100 g	—
Ambeed, Inc.	United States	$1.24	25 g	98%
Angene International Limited	United States	$9.96	25 g	95%
Angene	China → Hong Kong	$4266.67	30 mg	98%

Chemical Identity

CAS2370-88-9

PubChem CID75404

DTXSIDDTXSID10870958

FormulaC4H16O4Si4

Mol. Weight240.51 g/mol

SMILESC[SiH]1O[SiH](O[SiH](O[SiH](O1)C)C)C

Data Sources

EPA CompTox (DSSTox) · DTXSID10870958Retrieved 2026-04-06
PubChem · compound 75404Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

2,4,6,8-Tetramethylcyclotetrasiloxane (CAS 2370-88-9) https://chemicalindependence.com/chemical/2370-88-9/ EPA CompTox (DSSTox): DTXSID10870958. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID10870958 PubChem: 75404. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/75404 EPA Chemical Data Reporting: 2370-88-9. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 2370-88-9. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 293190 for CAS 2370-88-9. Reporting year: 2024. https://usatrade.census.gov/