Difluprednate

Drug ingredient

CAS 23674-86-4

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$1.1B

Top sourceSingapore 82%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293722 · basket

These shares come from HS customs code 293722, which covers 36 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

SG 82%SingaporeGB 15%United KingdomIT 2%Italy

India
Portugal
China
Mexico
Spain
Malaysia
Canada
Israel
Jordan
Belgium

14 FDA-registered drug labelers

Alembic Pharmaceuticals Inc.

Alembic Pharmaceuticals Limited

Amneal Pharmaceuticals NY LLC

Caplin Steriles Limited

Cipla USA Inc.

Dr. Reddy's Laboratories Inc.

Farmabios S.p.A.

Leading Pharma, LLC

Mylan Pharmaceuticals Inc.

Sandoz Inc

Sicor S.r.l.

Steroid S.p.A.

Tianjin Pacific Chemical and Pharmaceutical Co. Ltd.

Upsher-Smith Laboratories, LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 4 drug and cosmetic product listings (FDA).

•Difluprednate
•Difluprednate Ophthalmic Emulsion
•Difluprednate Ophthalmic
•Durezol

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS23674-86-4

PubChem CID443936

DTXSIDDTXSID0046773

FormulaC27H34F2O7

Mol. Weight508.5 g/mol

SMILESCCCC(=O)OC1(CCC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C(=O)COC(=O)C

Data Sources

PubChem · compound 443936Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Difluprednate (CAS 23674-86-4) https://chemicalindependence.com/chemical/23674-86-4/ PubChem: 443936. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/443936 FDA National Drug Code directory: CAS 23674-86-4. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293722 for CAS 23674-86-4. Reporting year: 2024. https://usatrade.census.gov/