Droxidopa

Drug ingredient

CAS 23651-95-8

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$652M

Top sourceSingapore 77%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292250 · basket

These shares come from HS customs code 292250, which covers 76 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

SG 77%SingaporeCN 12%ChinaIT 4%ItalyIN 2%IndiaGB 1%United Kingdom

Japan
Germany
Denmark
Taiwan
Spain
Bulgaria
Canada
Serbia
Switzerland
Sweden
South Korea
Netherlands
Hong Kong
Ukraine
Austria
Hungary
Belgium
Ireland
Israel
Finland
Mexico
Slovenia
Czech Republic
United Arab Emirates
Latvia

23 FDA-registered drug labelers

Apicore Pharmaceuticals Private Limited

Ascend Laboratories, LLC

Aurobindo Pharma Limited

Bionpharma Inc.

Camber Pharmaceuticals, Inc.

CivicaScript LLC

Clarochem Ireland Ltd

Dasami Lab Private Limited

Golden State Medical Supply, Inc.

Lundbeck Pharmaceuticals LLC

Lupin Pharmaceuticals, Inc.

MAJOR PHARMACEUTICALS

MSN Life Sciences Private Limited

Novadoz Pharmaceuticals LLC

Nuray Chemicals Private Limited

Piramal Pharma Limited

Quimica Sintetica S.A.

ScieGen Pharmaceuticals Inc

Slate Run Pharmaceuticals, LLC

Sumitomo Pharma Co., Ltd.

Sun Pharmaceutical Industries, Inc.

Zydus Lifesciences Limited

Zydus Pharmaceuticals USA Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Droxidopa
•Northera

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS23651-95-8

PubChem CID92974

DTXSIDDTXSID6046422

FormulaC9H11NO5

Mol. Weight213.19 g/mol

SMILESC1=CC(=C(C=C1C(C(C(=O)O)N)O)O)O

Data Sources

PubChem · compound 92974Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Droxidopa (CAS 23651-95-8) https://chemicalindependence.com/chemical/23651-95-8/ PubChem: 92974. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/92974 FDA National Drug Code directory: CAS 23651-95-8. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 292250 for CAS 23651-95-8. Reporting year: 2024. https://usatrade.census.gov/