Nalbuphine hydrochloride

Drug ingredient

CAS 23277-43-2

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 23277-43-2 — 1 HCl

US productionNot reported

Import value, 2024$50M

Top sourceIndia 37%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293919 · basket

These shares come from HS customs code 293919, which covers 12 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IN 37%IndiaIT 16%ItalyGB 15%United KingdomDE 10%GermanyDK 10%Denmark

Canada

12 FDA-registered drug labelers

FRANCOPIA

Henry Schein, Inc.

HF Acquisition Co LLC, DBA HealthFirst

Hospira, Inc.

LETCO MEDICAL, LLC

MAEDA INC

Medical Purchasing Solutions, LLC

Professional Compounding Centers of America dba PCCA

ProPharma Distribution

Sanofi Winthrop Industrie

Somerset Therapeutics, LLC

SpecGx LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Nalbuphine hydrochloride
•Nalbuphine HCI

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS23277-43-2

PubChem CID5360733

DTXSIDDTXSID20177844

FormulaC21H28ClNO4

Mol. Weight393.9 g/mol

SMILESC1CC(C1)CN2CCC34C5C(CCC3(C2CC6=C4C(=C(C=C6)O)O5)O)O.Cl

Data Sources

PubChem · compound 5360733Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Nalbuphine hydrochloride (CAS 23277-43-2) https://chemicalindependence.com/chemical/23277-43-2/ PubChem: 5360733. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5360733 FDA National Drug Code directory: CAS 23277-43-2. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293919 for CAS 23277-43-2. Reporting year: 2024. https://usatrade.census.gov/