2,2,4-Trimethyl-1,3- pentanediol diisobutyrate

CAS 22527-63-5

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$89M

Top sourceEstonia 32%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291631 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 291631, which covers 55 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

EE 32%EstoniaCN 30%ChinaNL 21%NetherlandsIT 5%ItalyIN 4%India

Germany
Malaysia
Switzerland
South Korea
Indonesia
Japan
Israel
Taiwan

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Eastman Chemical

Why It Matters

Sectors

Core Chemicals

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Plasticizer in All Other Basic Organic Chemical ManufacturingProcessing—incorporation into formulation, mixture, or reaction product

Chemical Identity

CAS22527-63-5

PubChem CID90798

DTXSIDDTXSID3027821

FormulaC19H28O4

Mol. Weight320.4 g/mol

SMILESCC(C)C(C(C)(C)COC(=O)C(C)C)OC(=O)C1=CC=CC=C1

Data Sources

EPA CompTox (DSSTox) · DTXSID3027821Retrieved 2026-04-06
PubChem · compound 90798Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

2,2,4-Trimethyl-1,3- pentanediol diisobutyrate (CAS 22527-63-5) https://chemicalindependence.com/chemical/22527-63-5/ EPA CompTox (DSSTox): DTXSID3027821. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID3027821 PubChem: 90798. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/90798 EPA Chemical Data Reporting: 22527-63-5. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 22527-63-5. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 291631 for CAS 22527-63-5. Reporting year: 2024. https://usatrade.census.gov/