Tetraammonium ethylenediaminetetraacetate

CAS 22473-78-5

U.S. production volumes are classified as confidential business information.

Molecular structure of 22473-78-5 — 4 NH₄⁺

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$503M

Import volumeZero

Top sourceChina 25%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292249 · basket

EPA reports by year

2023: US production Confidential · Imports Zero
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 292249, which covers 170 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 25%ChinaIN 17%IndiaSG 13%SingaporeIT 9%ItalyCH 7%Switzerland

Argentina
Poland
Portugal
Lithuania
Ukraine
Finland
Spain
Egypt
Sweden
Austria
Israel
Latvia
Belgium
Ireland
Mexico
Australia
Peru
Czech Republic
Colombia
Hong Kong

EPA-registered manufacturers (1)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Hawkins

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Dow Chemical

Why It Matters

Sectors

EnergyWaterCore Chemicals

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 4 sectors as 2 functional roles.

•Ion exchange agent in All Other Basic Organic Chemical Manufacturing (100%)Processing as a reactant
•Chelating agent in All Other Basic Organic Chemical Manufacturing (25%)Processing—incorporation into formulation, mixture, or reaction product
•Chelating agent in All Other Basic Inorganic Chemical Manufacturing (25%)Processing—incorporation into formulation, mixture, or reaction product
•Chelating agent in Utilities (25%)Processing—incorporation into formulation, mixture, or reaction product
•Chelating agent in Petroleum Refineries (25%)Processing—incorporation into formulation, mixture, or reaction product

Chemical Identity

CAS22473-78-5

PubChem CID15250631

DTXSIDDTXSID8027820

FormulaC10H28N6O8

Mol. Weight360.37 g/mol

SMILESC(CN(CC(=O)[O-])CC(=O)[O-])N(CC(=O)[O-])CC(=O)[O-].[NH4+].[NH4+].[NH4+].[NH4+]

Data Sources

EPA CompTox (DSSTox) · DTXSID8027820Retrieved 2026-04-06
PubChem · compound 15250631Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Tetraammonium ethylenediaminetetraacetate (CAS 22473-78-5) https://chemicalindependence.com/chemical/22473-78-5/ EPA CompTox (DSSTox): DTXSID8027820. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID8027820 PubChem: 15250631. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/15250631 EPA Chemical Data Reporting: 22473-78-5. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 22473-78-5. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 292249 for CAS 22473-78-5. Reporting year: 2024. https://usatrade.census.gov/