naproxen

Drug ingredient

CAS 22204-53-1

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 22204-53-1
US productionNot reported
Import value, 2024$370M
Top sourceIndia 45%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291899 · basket

These shares come from HS customs code 291899, which covers 139 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IN 45%IndiaCN 35%ChinaGB 7%United KingdomCO 3%ColombiaCH 3%Switzerland
56 FDA-registered drug labelers
A-S Medication Solutions
Acella Pharmaceuticals, LLC
Advanced Rx of Tennessee, LLC
Advanced Rx Pharmacy of Tennessee, LLC
Ajanta Pharma USA Inc.
American Health Packaging
Amneal Pharmaceuticals LLC
Amneal Pharmaceuticals NY LLC
Amneal Pharmaceuticals of New York LLC
ANI Pharmaceuticals, Inc.
Aphena Pharma Solutions - Tennessee, LLC
Asclemed USA Inc.
Aurobindo Pharma Limited
AvPAK
Boswell Pharmacy Services LLC d/b/a BPS Wholesale
Bryant Ranch Prepack
Camber Pharmaceuticals, Inc.
Cameron Pharmaceuticals
Cipla USA Inc.
Coupler LLC
DIRECT RX
Divi's Laboratories Limited
Dr. Reddy's Laboratories Limited
Exelan Pharmaceuticals, Inc.
Glenmark Pharmaceuticals Inc., USA
Granules Pharmaceuticals Inc.
HETERO LABS LIMITED
Hikma Pharmaceuticals USA Inc.
MARKSANS PHARMA LIMITED
Medcore LLC
Medisca Inc.
Medsource Pharmaceuticals
NCS HealthCare of KY, Inc dba Vangard Labs
Northwind Health Company, LLC
NuCare Pharmaceuticals, Inc.
Patheon Pharmaceuticals Inc.
PD-Rx Pharmaceuticals, Inc.
Pharmasource Meds, LLC
PHOENIX RX LLC
Preferred Pharmaceuticals Inc
Professional Compounding Centers of America dba PCCA
Proficient Rx LP
QPharma Inc
Quality Care Products, LLC
Radha Pharmaceuticals, Inc.
REMEDYREPACK INC.
ScieGen Pharmaceuticals, Inc
Spectrum Laboratory Products, Inc.
Sportpharm, Inc. dba Sportpharm
ST. MARY'S MEDICAL PARK PHARMACY
Sunrise Pharmaceutical, Inc.
TIME CAP LABORATORIES
TruPharma LLC
Xenex Laboratories Inc
Zameer Pharmaceuticals LLC
Zhejiang Charioteer Pharmaceutical Co., Ltd.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 4 drug and cosmetic product listings (FDA).

  • •Naproxen
  • •Naproxen and esomeprazole magnesium
  • •Naproxen Oral Suspension
  • •EC-Naproxen
FDA Shortage Status
No FDA shortage records

Vendor Pricing

$2.18/gAaron Chemicals LLC
CountryHong Kong
Pack$1091.00 / 500 g
Purity98%
Vendors27 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

Chemical Identity

CAS22204-53-1
PubChem CID156391
DTXSIDDTXSID4040686
FormulaC14H14O3
Mol. Weight230.26 g/mol
SMILESCC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O

Data Sources

Brief citations

naproxen (CAS 22204-53-1) https://chemicalindependence.com/chemical/22204-53-1/ PubChem: 156391. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/156391 FDA National Drug Code directory: CAS 22204-53-1. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 291899 for CAS 22204-53-1. Reporting year: 2024. https://usatrade.census.gov/