(1R,2S,5R)-(-)-Menthol
Drug ingredientCAS 2216-51-5
This drug ingredient has classified U.S. production volumes. EPA withholds the number as confidential business information.
US productionCBI
Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.
Import value, 2024$72M
Top sourceGermany 59%
At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.
Why supply is unknownProduction is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.
Where It Comes From
Customs basis: HS 290611 · narrow
EPA reports by year
- 2023
- US production Confidential · Imports Confidential
- 2019
- US production Confidential · Imports Confidential
These shares come from HS customs code 290611, which covers 4 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.
Source Countries
Country of origin for US imports, from Census customs data (2024).
DE 59%GermanyIN 35%IndiaSG 3%SingaporeMY 1%MalaysiaCN 1%China
- Guatemala
- Sweden
- Italy
- Netherlands
- Spain
- Taiwan
EPA-registered manufacturers (2)
Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.
Symrise Ag · DE Germany
Symrise
Domestic parents -- activity not disclosed (1)
EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.
Reckitt Benckiser
EPA-registered importers (7)
Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.
Basf Se · DE Germany
Reckitt Benckiser Group · GB United Kingdom
Basf
Berje
Henkel Us Operations
Show all 7
Takasago
Tilley Distribution
Why It Matters
Sectors
HealthFoodMetals & MiningConsumer ProductsCore Chemicals
Downstream Uses
Appears in 70 drug and cosmetic product listings (FDA).
- •Auvon 4% Menthol Pain Relief Gel
- •MQ Pain Relieving Patch
- •Dermoplast Pain Relieving
- •Satogesic
- •Tiger BALM PAIN Relieving
- •Cough Drops Dollar General Cherry 200ct
- •Freegells Cough Drops Menthol 30ct
- •4% lidocaine plus 1% menthol Pain Relief Patch
Show all 70
- •Knee Pain Relief Patch
- •Jeil Hangbang Paff Soo S Cataplasma
- •AVON HeXashield Pain Relief for Muscle, Back and Joint Cream
- •Tact Cool Jelly
- •TACT
- •Sinsinpas Arex Pain Relieving Patch, Medium
- •Cough Drops Dollar General Menthol 80ct
- •LidoSync
- •Cough Drops Freegells Strawberry 30ct
- •Rapid Relief
- •DR AMIN Javid Botanical-Complex Pain-Relieving Balm, 30 ml/1.0 fl oz
- •AREX Sinsin PAS
- •Sinsinpas Arex Flex Gel Pain Relieving Patch
- •Tiger Balm Pain Relieving Hydrogel Large
- •HealthWise 3x Medicated Pain Relief Patch
- •Menthol Drops Dollar General Severe Honey Lemon 45ct
- •Freegells Cough Drops Honey Lemon 30ct
- •Freegells Cough Drops Honey Lemon 200ct
- •Lekon Pain Relief Oil
- •Cough Drops Gems Flawless Honey Lemon Flavor 30ct
- •Cough Drops Dollar General Menthol 160ct
- •Avcoo Menthol Pain Relief Patch
- •Wen Tong Gao
- •Satohap
- •Satohap Cool Type
- •Cough Drops Dollar General Menthol 30ct
- •Freegells Cough Drops Menthol Cherry 30ct
- •Auvon Lidocaine Menthol Pain Relief Patch
- •HealthWise 3x Medicated Pain Relief Patch 120 Bulk
- •Freegells Cough Drops Menthol Cherry 80ct
- •LK Herbal Patch
- •Zenol COOL
- •Sinsin Mulpas
- •Xencare Inflamax Natural Topical PAIN
- •GuruNanda Pain Relief
- •Menthol Drops Dollar General Severe 45ct
- •Up up
- •Ultra Strength Topical Pain Relief Cream
- •Freegells Cough Drops Menthol 80ct
- •5% Menthol Pain Relief Patch
- •Kalaya Extra Strength Pain Relief Cream with Hemp Seed Oil
- •Satohap Lidocaine 4% Menthol 1% Pain Relieving Cream
- •Elizabeth Health Style Chestrub Vaporizing Action
- •Sinsinpap COOL
- •Pain Relief
- •Cough Drops Gems Flawless Cherry Flavor 30ct
- •Antiphlamine
- •PAIN Relief Menthol AND HEMP
- •Cough Drops Dollar General Strawberry 30ct
- •Maximum Strenght Lidocaine plus Menthol Pain Relief Patch
- •Satohap Cool and Hot Pads
- •Careall Muscle Rub Ultra Strength
- •Tiger BALM PAIN Relieving Hydrogel
- •GuruNanda Oral Pain Relief
- •Cough Drops Dollar General Cherry 30ct
- •Cough Drops Dollar General Honey Lemon 30ct
- •Cough Drops Dollar General Honey Lemon 200ct
- •Zenol Double Action
- •Kalaya Extra Strength Pain Relief Gel with Arnica
- •Satohap COOL and HOT
- •Sinsinpas arex patch large
- •CVS Health Maximum Strength Lidocaine Pain Relief Cream Plus Menthol
FDA Shortage Status
Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."
No FDA shortage records
Industrial Uses
Used in 6 sectors as 4 functional roles.
- •Flavoring and nutrient in Food, beverage, and tobacco product manufacturingProcessing—incorporation into formulation, mixture, or reaction product
- •Fragrance in All Other Basic Organic Chemical ManufacturingProcessing—incorporation into formulation, mixture, or reaction product
- •Fragrance in Not Known or Reasonably Ascertainable (100%)Not Known or Reasonably Ascertainable
- •Fixing agent (mordant) in All Other Chemical Product and Preparation Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
- •Fragrance in Other (100%)Processing—incorporation into formulation, mixture, or reaction product
- •Fragrance in Soap, Cleaning Compound, and Toilet Preparation ManufacturingProcessing—incorporation into formulation, mixture, or reaction product
- •Odor agents in All Other Basic Organic Chemical Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
Vendor Pricing
$0.12/gSigma-Aldrich (Rush Stock)
CountryGermany
Pack$488.49 / 4 kg
Purity95%
Vendors21 available
Prices reflect listed pack sizes. Small research packs run far above bulk rates.
20 more vendors
| Vendor | Country Supplier country. Where available, shows shipping origin. When the supplier ships from a different country than where they are registered, both are shown. Most suppliers show registration country only. | $/g | Pack | Purity |
|---|---|---|---|---|
| Sigma-Aldrich | Germany | $0.12 | 4 kg | 95% |
| Combi-Blocks, Inc. | United States | $0.25 | 1 kg | 97% |
| AK Scientific Specialized | United States | $0.29 | 500 g | 95% |
| AK Scientific, Inc. | United States | $0.38 | 500 g | 99% |
| Aaron Chemicals LLC | Hong Kong | $0.58 | 100 g | 97% |
| Ambeed, Inc. | United States | $0.62 | 100 g | 98% |
| Angene Chemical | China → Hong Kong | $0.69 | 100 g | 97% |
| A2B Chem LLC | United States | $0.76 | 25 g | 98% |
| AA BLOCKS | United States | $0.84 | 25 g | 98% |
| Fluorochem UK | United Kingdom | $12.87 | 1 g | 97% |
| Interbioscreen | Hong Kong | $34.00 | 10 g | 95% |
| Molnova | China | $380.00 | 100 mg | 99% |
| TargetMol Chemicals | China → United States | $420.00 | 100 mg | 99.88% |
| Apexbio Technology LLC | United States | $425.00 | 200 mg | 98% |
| ChemFaces | China | $1500.00 | 20 mg | 98% |
| Otava, Ltd. (2 weeks) | Ukraine | $2724.00 | 50 mg | 90% |
| Princeton BioMolecular Research (SC) | United States | $2900.00 | 100 mg | 90% |
| Vitas M Chemical Limited | Hong Kong | $3170.00 | 100 mg | 90% |
| Angene | China → Hong Kong | $4266.67 | 30 mg | 97% |
| AstaTech (2 weeks) | United States | $11900.00 | 10 mg | 95% |
Chemical Identity
CAS2216-51-5
PubChem CID16666
DTXSIDDTXSID1022180
FormulaC10H20O
Mol. Weight156.26 g/mol
SMILESCC1CCC(C(C1)O)C(C)C
Data Sources
- EPA CompTox (DSSTox) · DTXSID1022180Retrieved 2026-04-06
- PubChem · compound 16666Retrieved 2026-04-06
- EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
- EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
- US Census international tradeReporting year: 2024 · Retrieved 2026-10-04
Brief citations
(1R,2S,5R)-(-)-Menthol (CAS 2216-51-5) https://chemicalindependence.com/chemical/2216-51-5/ EPA CompTox (DSSTox): DTXSID1022180. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID1022180 PubChem: 16666. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/16666 EPA Chemical Data Reporting: 2216-51-5. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 2216-51-5. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 290611 for CAS 2216-51-5. Reporting year: 2024. https://usatrade.census.gov/