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Imatinib mesylate

Drug ingredient

CAS 220127-57-1

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 220127-57-1
US productionNot reported
Import value, 2024$7.6B
Top sourceIreland 61%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India
36 FDA-registered drug labelers
American Health Packaging
Apotex Corp
Archis Pharma LLC
Armas Pharmaceuticals Inc.
Ascend Laboratories, LLC
Aurobindo Pharma Limited
BluePoint Laboratories
Camber Pharmaceuticals, Inc.
Chartwell RX, LLC
DARMERICA, LLC
Dr.Reddy's Laboratories Inc
Dr.Reddy's Laboratories Limited
F.I.S. FABBRICA ITALIANA SINTETICI S.P.A.
Golden State Medical Supply, Inc.
Hetero Labs Limited
Hubei Biocause Heilen Pharmaceutical Co., Ltd
LAURUS LABS LIMITED
Major Pharmaceuticals
MSN Laboratories Private Limited
Mylan Institutional Inc
Mylan Pharmaceuticals Inc.
Natco Pharma Limited
Novartis Pharma Produktions GmbH
Novartis Pharmaceuticals Corporation
Qilu Pharmaceutical Co., Ltd.
QUALLENT PHARMACEUTICALS HEALTH LLC
SHILPA PHARMA LIFESCIENCES LIMITED
Shorla Oncology Inc.,
Sterling Pharma Solutions Limited
SUN PHARMACEUTICAL INDUSTRIES, INC.
TAPI Croatia Industries Ltd.
Teva Pharmaceuticals USA, Inc.
Upsher-Smith Laboratories, LLC
Valary Lab Private Limited
Zhejiang Ausun Pharmaceutical Co., Ltd.
zhejiang jiuzhou pharmaceutical Co., Ltd.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 5 drug and cosmetic product listings (FDA).

  • •Imatinib mesylate 400 mg
  • •imatinib mesylate
  • •Gleevec
  • •Imatinib
  • •Imkeldi
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS220127-57-1
PubChem CID123596
DTXSIDDTXSID9040502
FormulaC30H35N7O4S
Mol. Weight589.7 g/mol
SMILESCC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O

Data Sources

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Brief citations

Imatinib mesylate (CAS 220127-57-1) https://chemicalindependence.com/chemical/220127-57-1/ PubChem: 123596. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/123596 FDA National Drug Code directory: CAS 220127-57-1. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293359 for CAS 220127-57-1. Reporting year: 2024. https://usatrade.census.gov/