Hydroxyzine dihydrochloride

Drug ingredient

CAS 2192-20-3

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 2192-20-3
2 HCl
US productionNot reported
Import value, 2024$7.6B
Top sourceIreland 61%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India
60 FDA-registered drug labelers
A-S Medication Solutions
Advanced Rx of Tennessee, LLC
Advanced Rx Pharmacy of Tennessee, LLC
American Health Packaging
American Regent, Inc.
Amneal Pharmaceuticals LLC
ANI Pharmaceuticals, Inc.
Aphena Pharma Solutions - Tennessee, LLC
APOZEAL PHARMACEUTICALS INC
Asclemed USA, Inc.
ATLANTIC BIOLOGICALS CORP.
Aurobindo Pharma Limited
Bionpharma Inc.
Bryant Ranch Prepack
Calyx Chemicals & Pharmaceuticals
Camber Pharmaceuticals, Inc.
Cardinal Health 107, LLC
Chartwell Governmental & Specialty RX, LLC.
Chartwell RX, LLC
Chemische Fabrik Berg GmbH
COSMA Spa
Direct Rx
Epic Pharma, LLC
Fagron Inc
Glochem Industries Private Limited
Golden State Medical Supply, Inc.
Henry Schein, Inc.
Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.
HF Acquisition Co LLC, DBA HealthFirst
Ipca Laboratories Limited
Kesin Pharma
Kreative Organics Private Limited
KVK-Tech, Inc.
Lannett Company, Inc.
LETCO MEDICAL, LLC
MAHI DRUGS PRIVATE LIMITED
Major Pharmaceuticals
Marlex Pharmaceuticals, Inc.
McKesson Corporation dba SKY Packaging
Medisca Inc.
Medsource Pharmaceuticals
NCS HealthCare of KY, LLC dba Vangard Labs
Northstar RxLLC
Northwind Health Company, LLC
NuCare Pharmaceuticals, Inc
PAI Holdings, LLC dba PAI Pharma
PD-Rx Pharmaceuticals, Inc.
Preferred Pharmaceuticals Inc.
Preferred Pharmaceuticals Incl
Professional Compounding Centers of America
Proficient Rx LP
PURACAP LABORATORIES LLC DBA BLU PHARMACEUTICALS
REMEDYREPACK INC.
Rising Pharma Holdings, Inc.
Spectrum Laboratory Products, Inc.
ST. MARY'S MEDICAL PARK PHARMACY
Sunrise Pharmaceutical, Inc.
Symed Labs Limited
Teva Pharmaceuticals USA, Inc.
Vijayasri Organics Private Limited

Why It Matters

Sectors
Health
Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

  • •Hydroxyzine Hydrochloride
  • •Hydroxyzine HCL
  • •Hydroxyzine
FDA Shortage Status
No FDA shortage records

Vendor Pricing

$1.96/gAK Scientific Specialized
CountryUnited States
Pack$980.00 / 500 g
Purity95%
Vendors15 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

Chemical Identity

CAS2192-20-3
PubChem CID91513
DTXSIDDTXSID2040737
FormulaC21H29Cl3N2O2
Mol. Weight447.8 g/mol
SMILESC1CN(CCN1CCOCCO)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl.Cl.Cl

Data Sources

Brief citations

Hydroxyzine dihydrochloride (CAS 2192-20-3) https://chemicalindependence.com/chemical/2192-20-3/ PubChem: 91513. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/91513 EPA TSCA Inventory: CAS 2192-20-3. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293359 for CAS 2192-20-3. Reporting year: 2024. https://usatrade.census.gov/