Lofexidine hydrochloride

Drug ingredient

CAS 21498-08-8

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 21498-08-8 — 1 HCl

US productionNot reported

Top sourceNo public record

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Where It Comes From

EPA and Census publish no US supply data for this chemical.

12 FDA-registered drug labelers

ANI Pharmaceuticals, Inc.

Catalent Pharma Solutions, LLC

Florida Pharmaceutical Products, LLC

HAS Healthcare Advanced Synthesis SA

Indoco Remedies Limited

Medichem Manufacturing (Malta) Ltd.

Medichem S.A.

MSN Laboratories Private Limited

Novadoz Pharmaceuticals LLC

Prasco Laboratories

Procos SpA

USWM, LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

•Lofexidine
•Lucemyra
•Lofexidine hydrochloride

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$95.00/gA2B Chem LLC

CountryUnited States

Pack$95.00 / 1 g

Purity98%

Vendors8 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

7 more vendors

Vendor	Country	$/g	Pack	Purity
AA BLOCKS	United States	$105.00	1 g	98%
Cayman Europe	Estonia	$149.94	1 g	98%
Combi-Blocks (back-ordered)	United States	$350.00	1 g	98%
MedKoo Biosciences, Inc	United States	$550.00	1 g	98%
MedChemExpress MCE	Sweden	$689.70	100 mg	99.74%
Angene International Limited	United States	$1700.00	100 mg	98%
Aaron Chemicals LLC	Hong Kong	$7120.00	25 mg	—

Chemical Identity

CAS21498-08-8

PubChem CID30667

DTXSIDDTXSID0020781

FormulaC11H13Cl3N2O

Mol. Weight295.6 g/mol

SMILESCC(C1=NCCN1)OC2=C(C=CC=C2Cl)Cl.Cl

Data Sources

PubChem · compound 30667Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07

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Brief citations

Lofexidine hydrochloride (CAS 21498-08-8) https://chemicalindependence.com/chemical/21498-08-8/ PubChem: 30667. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/30667 FDA National Drug Code directory: CAS 21498-08-8. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/