Pirtobrutinib

Drug ingredient

CAS 2101700-15-4

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$597M

Top sourceSwitzerland 53%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293319 · basket

These shares come from HS customs code 293319, which covers 133 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CH 53%SwitzerlandDE 22%GermanyIN 14%IndiaCN 4%ChinaIT 3%Italy

Sweden
Ukraine
Taiwan
Spain
Canada
Portugal
Slovakia
New Zealand
Netherlands
Croatia
Latvia

5 FDA-registered drug labelers

Eli Lilly and Company

Eli Lilly Kinsale Limited

HOVIONE FARMACIENCIA SA

MSN Laboratories Private Limited

TAPI Hungary Industries Kft.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Jaypirca

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS2101700-15-4

PubChem CID129269915

DTXSIDDTXSID301358726

FormulaC22H21F4N5O3

Mol. Weight479.4 g/mol

SMILESCC(C(F)(F)F)N1C(=C(C(=N1)C2=CC=C(C=C2)CNC(=O)C3=C(C=CC(=C3)F)OC)C(=O)N)N

Data Sources

PubChem · compound 129269915Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Pirtobrutinib (CAS 2101700-15-4) https://chemicalindependence.com/chemical/2101700-15-4/ PubChem: 129269915. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/129269915 FDA National Drug Code directory: CAS 2101700-15-4. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293319 for CAS 2101700-15-4. Reporting year: 2024. https://usatrade.census.gov/