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Propofol

Drug ingredient

CAS 2078-54-8

This drug ingredient has classified U.S. production volumes. EPA withholds the number as confidential business information.

Molecular structure of 2078-54-8
US productionCBI
Import value, 2024$33M
Top sourceGermany 29%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 290719 · basket

EPA reports by year
2023
US production Confidential · Imports Confidential

These shares come from HS customs code 290719, which covers 116 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
DE 29%GermanyIN 26%IndiaCN 19%ChinaIT 9%ItalyCH 5%Switzerland
Domestic parents -- activity not disclosed (1)
Si Group
23 FDA-registered drug labelers
Amneal Pharmaceuticals Private Limited
Avenacy, LLC
Bachem SA, succursale de Vionnaz
Civica, Inc
Curia Italy S.r.l.
Dr. Reddy's Laboratories, Inc.
Emcure Pharmaceuticals Limited
F.I.S. Fabbrica Italiana Sintetici S.P.A.
Fresenius Kabi USA, LLC
Harman Finochem Limited
Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.
HF Acquisition Co LLC, DBA HealthFirst
Hikma Pharmaceuticals USA Inc.
Hospira, Inc.
Meitheal Pharmaceuticals Inc.
Neuland Laboratories Limited
NorthStar Rx LLC
Pfizer Laboratories Div Pfizer Inc
Porton Pharma Solutions Ltd
Professional Compounding Centers of America
Professional Compounding Centers of America dba PCCA
Sagent Pharmaceuticals
SI Group, Inc.

Why It Matters

Sectors
HealthCore Chemicals
Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

  • •propofol
  • •Propofol Injectable Emulsion
  • •Diprivan
FDA Shortage Status
No FDA shortage records

Industrial Uses

  • •Intermediate in All Other Basic Organic Chemical Manufacturing (100%)Processing as a reactant

Vendor Pricing

$0.28/gCombi-Blocks, Inc.
CountryUnited States
Pack$280.00 / 1 kg
Purity98%
Vendors9 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

8 more vendors
VendorCountry$/gPackPurity
AK Scientific SpecializedUnited States$0.32500 g95%
AK Scientific, Inc.United States$0.43500 g95%
Sigma-Aldrich (Rush Stock)Germany$0.58100 g97%
Sigma-AldrichGermany$0.58100 g97%
AstaTech, IncUnited States$0.87500 g95%
MedChemExpress MCESweden$30.6110 g99.82%
CliniSciences GmbHSwitzerland$348.30100 mg99%
MolnovaChina$1560.0025 mg99%

Chemical Identity

CAS2078-54-8
PubChem CID4943
DTXSIDDTXSID6023523
FormulaC12H18O
Mol. Weight178.27 g/mol
SMILESCC(C)C1=C(C(=CC=C1)C(C)C)O

Data Sources

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Brief citations

Propofol (CAS 2078-54-8) https://chemicalindependence.com/chemical/2078-54-8/ PubChem: 4943. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/4943 EPA Chemical Data Reporting: 2078-54-8. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 290719 for CAS 2078-54-8. Reporting year: 2024. https://usatrade.census.gov/