4-Formyl-2-methoxyphenyl isobutyrate

CAS 20665-85-4

Companies reported imports and no US production of this chemical to EPA for 2023.

US productionZero

Import value, 2024$63M

Import volume19.6K lb

Import dependency100%

Top sourceChina 22%

Production is reported production, not a complete census of factories. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

4-Formyl-2-methoxyphenyl isobutyrate · US import value by year

2013: $31M · Peak 2022: $85M · 2024: $63M · 2025: $50M

Where It Comes From

Customs basis: HS 291560 · basket

EPA reports by year

2023: US production Zero · Imports 19.6K lb
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 291560, which covers 183 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 22%ChinaDE 19%GermanySE 14%SwedenJP 13%JapanIN 9%India

Ireland
South Korea
United Arab Emirates
Russia
Ukraine
Israel
Brazil
Canada

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Reckitt Benckiser

EPA-registered importers (1)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Givaudan Fragrances

Why It Matters

Sectors

Core Chemicals

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Fragrance in All Other Chemical Product and Preparation Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product

Vendor Pricing

$0.23/gAaron Chemicals LLC

CountryHong Kong

Pack$116.00 / 500 g

Purity98%

Vendors17 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

16 more vendors

Vendor	Country	$/g	Pack	Purity
Angene Chemical	China → Hong Kong	$0.24	500 g	98%
Sigma-Aldrich (Rush Stock)	Germany	$0.25	5 kg	98%
Sigma-Aldrich	Germany	$0.25	5 kg	98%
A2B Chem LLC	United States	$0.30	500 g	98%
Combi-Blocks, Inc.	United States	$0.30	500 g	98%
BLD Pharmatech Ltd.	China	$0.33	500 g	98%
AA BLOCKS	United States	$0.37	500 g	98%
MedChemExpress MCE	Sweden	$0.39	500 g	—
BLD Pharmatech GmbH	Germany	$0.50	100 g	98%
Ambeed, Inc.	United States	$0.50	100 g	98%
BLD Pharmatech Co., Limited	United States	$0.96	25 g	98%
AK Scientific Specialized	United States	$3.08	25 g	95%
AstaTech (2 weeks)	United States	$4.08	25 g	95%
AK Scientific, Inc.	United States	$4.24	25 g	98%
Angene International Limited	United States	$7.92	25 g	98%
Angene	China → Hong Kong	$4266.67	30 mg	98%

Chemical Identity

CAS20665-85-4

PubChem CID539829

DTXSIDDTXSID9047201

FormulaC12H14O4

Mol. Weight222.24 g/mol

SMILESCC(C)C(=O)OC1=C(C=C(C=C1)C=O)OC

Data Sources

EPA CompTox (DSSTox) · DTXSID9047201Retrieved 2026-04-06
PubChem · compound 539829Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

4-Formyl-2-methoxyphenyl isobutyrate (CAS 20665-85-4) https://chemicalindependence.com/chemical/20665-85-4/ EPA CompTox (DSSTox): DTXSID9047201. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID9047201 PubChem: 539829. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/539829 EPA Chemical Data Reporting: 20665-85-4. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 20665-85-4. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 291560 for CAS 20665-85-4. Reporting year: 2024. https://usatrade.census.gov/