Ramelteon

Drug ingredient

CAS 196597-26-9

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$3.5B

Top sourceIreland 57%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293299 · basket

These shares come from HS customs code 293299, which covers 229 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 57%IrelandNL 24%NetherlandsCH 8%SwitzerlandCN 5%ChinaIT 2%Italy

United Kingdom
Japan
Germany
Spain
Israel
Canada
Brazil
Vietnam
Ukraine
New Zealand
Belgium
Mexico
Singapore
Taiwan
South Korea
Sweden
South Africa
Egypt
Indonesia
Lithuania
Finland
Hungary
Czech Republic
Hong Kong
Malaysia
Slovakia
Australia
Russia
Jordan
Latvia
Argentina
Slovenia
Malta
Poland
Denmark
Austria

32 FDA-registered drug labelers

Actavis Pharma, Inc.

Advanced Rx Pharmacy of Tennessee, LLC

American Health Packaging

Asclemed USA, Inc.

Assia Chemical Industries Ltd - Teva Tech Site

Aurobindo Pharma Limited

AvKARE

AvPAK

Biophore India Pharmaceuticals Private Limited

Bryant Ranch Prepack

Cutyx Research LLP

DIRECT RX

Dr.Reddys Laboratories Inc

Enaltec Labs Pvt Ltd

Golden State Medical Supply, Inc.

Granules Pharmaceuticals Inc.

i3 Pharmaceuticals, LLC

Major Pharmaceuticals

Micro Labs Limited

MSN Laboratories Private Limited

NURAY CHEMICALS PRIVATE LIMITED

Proficient Rx LP

Quality Care Products, LLC

REMEDYREPACK INC.

Takeda Ireland Ltd.

Takeda Pharmaceuticals America, Inc.

TruPharma, LLC

Upsher-Smith Laboratories, LLC

Xiromed, LLC

Zhejiang Ausun Pharmaceutical Co., Ltd.

Zydus Lifesciences Limited

Zydus Pharmaceuticals USA Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Ramelteon
•Rozerem

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

to be discontinued
Ramelteon Tablet
Shortage listed since March 19, 2026

See all current drug shortages

Chemical Identity

CAS196597-26-9

PubChem CID208902

DTXSIDDTXSID6045951

FormulaC16H21NO2

Mol. Weight259.34 g/mol

SMILESCCC(=O)NCCC1CCC2=C1C3=C(C=C2)OCC3

Data Sources

PubChem · compound 208902Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Ramelteon (CAS 196597-26-9) https://chemicalindependence.com/chemical/196597-26-9/ PubChem: 208902. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/208902 FDA National Drug Code directory: CAS 196597-26-9. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 196597-26-9. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293299 for CAS 196597-26-9. Reporting year: 2024. https://usatrade.census.gov/