Tiopronin

Drug ingredient

CAS 1953-02-2

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$760M

Top sourceChina 33%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293090 · basket

These shares come from HS customs code 293090, which covers 418 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 33%ChinaES 14%SpainCH 9%SwitzerlandIT 7%ItalyIN 7%India

Israel
Croatia
Ukraine
Slovakia
United Arab Emirates
Ireland
Poland
Lithuania
Brazil
Singapore
Australia
Armenia
Hong Kong
Vietnam
Czech Republic
Hungary
Greece
Russia

14 FDA-registered drug labelers

Amneal Pharmaceuticals NY LLC

Azico Biophore India Private Limited

BioComp Pharma, Inc.

Cycle Pharmaceuticals Ltd.

Dasami Lab Private Limited

Endo USA, Inc.

Mission Pharmacal Company

MSN Life Sciences Private Limited

Nuray Chemicals Private Limited

Porton Pharma Solutions Ltd

SCL Lifesciences Limited

Teva Pharmaceuticals USA, Inc.

Teva Pharmaceuticals, Inc.

Torrent Pharmaceuticals Limited

Why It Matters

Sectors

Health

Downstream Uses

Appears in 4 drug and cosmetic product listings (FDA).

•Tiopronin
•Thiola
•Thiola EC
•Venxxiva

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$1.03/gA2B Chem LLC

CountryUnited States

Pack$103.00 / 100 g

Purity98%

Vendors18 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

17 more vendors

Vendor	Country	$/g	Pack	Purity
Aaron Chemicals LLC	Hong Kong	$1.10	100 g	98%
AA BLOCKS	United States	$1.20	25 g	98%
AK Scientific Specialized	United States	$1.20	100 g	95%
Angene Chemical	China → Hong Kong	$1.24	500 g	98%
Ambeed, Inc.	United States	$1.32	100 g	98%
Combi-Blocks, Inc.	United States	$1.40	25 g	98%
AK Scientific, Inc.	United States	$1.61	100 g	97%
Angene International Limited	United States	$2.83	100 g	97%
Cayman Europe	Estonia	$27.13	5 g	98%
Sigma-Aldrich (Rush Stock)	Germany	$36.03	10 g	—
Sigma-Aldrich	Germany	$36.03	10 g	—
TargetMol Chemicals	China → United States	$39.00	1 g	99.97%
MedChemExpress MCE	Sweden	$62.92	1 g	98%
Molnova	China	$380.00	200 mg	99%
Labotest KG	Germany	$453.00	1000 mg	90%
Angene	China → Hong Kong	$4266.67	30 mg	98%
Key Organics Ltd.	United Kingdom	$6900.00	10 mg	97%

Chemical Identity

CAS1953-02-2

PubChem CID5483

DTXSIDDTXSID4023678

FormulaC5H9NO3S

Mol. Weight163.2 g/mol

SMILESCC(C(=O)NCC(=O)O)S

Data Sources

PubChem · compound 5483Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Tiopronin (CAS 1953-02-2) https://chemicalindependence.com/chemical/1953-02-2/ PubChem: 5483. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5483 FDA National Drug Code directory: CAS 1953-02-2. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293090 for CAS 1953-02-2. Reporting year: 2024. https://usatrade.census.gov/