Difluoromethyl 2,2,2-trifluoroethyl ether

CAS 1885-48-9

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$117M

Top sourceIndia 29%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 290919 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 290919, which covers 93 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IN 29%IndiaCN 25%ChinaJP 20%JapanBR 6%BrazilDE 4%Germany

South Korea
Singapore
Spain
United Arab Emirates
Netherlands
Belgium
Indonesia
Poland
Mexico
Taiwan
Slovakia

Why It Matters

Sectors

Health

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Intermediate in Pharmaceutical and Medicine ManufacturingProcessing as a reactant

Vendor Pricing

$66.60/gA2B Chem LLC (1 week)

CountryUnited States

Pack$333.00 / 5 g

Purity98%

Vendors3 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

2 more vendors

Vendor	Country	$/g	Pack	Purity
AA BLOCKS (1 week)	United States	$73.40	5 g	98%
MedChemExpress MCE	Sweden	$74.54	5 g	99.41%

Chemical Identity

CAS1885-48-9

PubChem CID74668

DTXSIDDTXSID5073951

FormulaC3H3F5O

Mol. Weight150.05 g/mol

SMILESC(C(F)(F)F)OC(F)F

Data Sources

EPA CompTox (DSSTox) · DTXSID5073951Retrieved 2026-04-06
PubChem · compound 74668Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Difluoromethyl 2,2,2-trifluoroethyl ether (CAS 1885-48-9) https://chemicalindependence.com/chemical/1885-48-9/ EPA CompTox (DSSTox): DTXSID5073951. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID5073951 PubChem: 74668. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/74668 EPA Chemical Data Reporting: 1885-48-9. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 1885-48-9. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 290919 for CAS 1885-48-9. Reporting year: 2024. https://usatrade.census.gov/