Ketamine hydrochloride

Drug ingredient

CAS 1867-66-9

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 1867-66-9 — 1 HCl

US productionNot reported

Import value, 2024$21M

Top sourceIndia 59%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292239 · basket

These shares come from HS customs code 292239, which covers 30 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IN 59%IndiaDE 15%GermanyCN 14%ChinaIT 10%ItalyES 2%Spain

Canada
Netherlands
Switzerland
Ukraine
Japan
United Kingdom
Taiwan

27 FDA-registered drug labelers

Arevipharma GmbH

AX Pharmaceutical Corp

Baxter Healthcare Corporation

Civica, Inc.

CU Chemie Uetikon GmbH

CU Chemie Uetikon GmbH (340717289)

Eugia US LLC

Fagron Inc

Fresenius Kabi USA, LLC

Gland Pharma Limited

Henry Schein, Inc

Hikma Pharmaceuticals USA Inc.

Hospira, Inc.

Kalchem International inc

LETCO MEDICAL, LLC

Maithri Drugs Private Limited

Medical Purchasing Solutions, LLC

Medisca Inc.

NORCHIM

Par Health USA, LLC

PCAS

Pharma Source Direct, Inc.

Professional Compounding Centers of America

Professional Compounding Centers of America dba PCCA

Sagent Pharmaceuticals

Spectrum Laboratory Products, Inc.

Supriya Lifescience Limited

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Ketamine Hydrochloride
•Ketalar

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

to be discontinued
Ketamine Hydrochloride Injection
Shortage listed since November 7, 2025

See all current drug shortages

Chemical Identity

CAS1867-66-9

PubChem CID15851

DTXSIDDTXSID4040137

FormulaC13H17Cl2NO

Mol. Weight274.18 g/mol

SMILESCNC1(CCCCC1=O)C2=CC=CC=C2Cl.Cl

Data Sources

PubChem · compound 15851Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Ketamine hydrochloride (CAS 1867-66-9) https://chemicalindependence.com/chemical/1867-66-9/ PubChem: 15851. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/15851 FDA National Drug Code directory: CAS 1867-66-9. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 1867-66-9. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 292239 for CAS 1867-66-9. Reporting year: 2024. https://usatrade.census.gov/