Zibotentan

Drug ingredient

CAS 186497-07-4

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$2.0B

Top sourceIreland 63%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293590 · basket

These shares come from HS customs code 293590, which covers 182 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 63%IrelandSG 14%SingaporeIN 7%IndiaCN 7%ChinaCH 2%Switzerland

Portugal
Spain
Italy
Austria
Israel
Hungary
Canada
South Korea
Netherlands
Finland
Poland
Indonesia
Ukraine
Mexico
South Africa
Croatia
Greece
Taiwan
Hong Kong

1 FDA-registered drug labeler

Lonza AG

Why It Matters

Sectors

Health

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$4928.00/gCombi-Blocks (back-ordered)

CountryUnited States

Pack$1232.00 / 250 mg

Purity95%

Vendors18 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

17 more vendors

Vendor	Country	$/g	Pack	Purity
Angene Chemical	China → Hong Kong	$6700.00	250 mg	98%
Aaron Chemicals LLC	Hong Kong	$7320.00	100 mg	98%
A2B Chem LLC	United States	$7520.00	25 mg	98%
BLD Pharmatech Ltd.	China	$7590.00	100 mg	98%
AA BLOCKS	United States	$8360.00	25 mg	98%
Ambeed, Inc.	United States	$8980.00	50 mg	98%
BLD Pharmatech GmbH	Germany	$10480.00	25 mg	98%
BLD Pharmatech Co., Limited	United States	$10560.00	25 mg	98%
MedChemExpress MCE	Sweden	$10805.30	100 mg	99.66%
TargetMol Chemicals	China → United States	$11880.00	25 mg	99.57%
Angene International Limited	United States	$14100.00	100 mg	98%
Apexbio Technology LLC	United States	$18360.00	25 mg	99.76%
AstaTech (2 weeks)	United States	$19000.00	25 mg	98%
Cayman Europe	Estonia	$24038.00	25 mg	98%
Sigma-Aldrich (Rush Stock)	Germany	$29518.80	25 mg	98%
Sigma-Aldrich	Germany	$29518.80	25 mg	98%
MedKoo Biosciences, Inc	United States	$38000.00	25 mg	98%

Chemical Identity

CAS186497-07-4

PubChem CID9910224

DTXSIDDTXSID70870171

FormulaC19H16N6O4S

Mol. Weight424.4 g/mol

SMILESCC1=CN=C(C(=N1)OC)NS(=O)(=O)C2=C(N=CC=C2)C3=CC=C(C=C3)C4=NN=CO4

Data Sources

PubChem · compound 9910224Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Zibotentan (CAS 186497-07-4) https://chemicalindependence.com/chemical/186497-07-4/ PubChem: 9910224. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/9910224 FDA National Drug Code directory: CAS 186497-07-4. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293590 for CAS 186497-07-4. Reporting year: 2024. https://usatrade.census.gov/