chlorhexidine digluconate

Drug ingredient

CAS 18472-51-0

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$240M

Top sourceChina 37%

EPA lists this chemical for 2023 but publishes zero or no volume for both production and imports.

Why supply is unknown

Production is reported production, not a complete census of factories. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292529 · basket

EPA reports by year

2023: US production Not published · Imports Not published

These shares come from HS customs code 292529, which covers 64 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 37%ChinaDE 19%GermanyES 9%SpainIT 8%ItalyID 8%Indonesia

Switzerland
Canada
United Kingdom
Austria
Brazil
Israel
Australia
Hungary
Serbia
Denmark
Malaysia
Poland
Hong Kong
Ukraine
Singapore

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Cps Performance Materials

3 FDA-registered drug labelers

Guangdong Quadrant Ecological Technology Co., Ltd.

GUANGZHOU SAWEILAN IMPORT & EXPORT TRADING CO., LTD

MY CUTENESS LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

•Nourishing HAND Sanitizer Sprays
•Seacall Mouthwash
•MyCuteness Pet Dental Care Water Additive

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS18472-51-0

PubChem CID9552081

DTXSIDDTXSID5034519

FormulaC34H54Cl2N10O14

Mol. Weight897.8 g/mol

SMILESC1=CC(=CC=C1NC(=NC(=NCCCCCCN=C(N)N=C(N)NC2=CC=C(C=C2)Cl)N)N)Cl.C(C(C(C(C(C(=O)O)O)O)O)O)O.C(C(C(C(C(C(=O)O)O)O)O)O)O

Data Sources

PubChem · compound 9552081Retrieved 2026-04-07
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

chlorhexidine digluconate (CAS 18472-51-0) https://chemicalindependence.com/chemical/18472-51-0/ PubChem: 9552081. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/9552081 EPA Chemical Data Reporting: 18472-51-0. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 292529 for CAS 18472-51-0. Reporting year: 2024. https://usatrade.census.gov/