Erlotinib hydrochloride

Drug ingredient

CAS 183319-69-9

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 183319-69-9 — 1 HCl

US productionNot reported

Import value, 2024$7.6B

Top sourceIreland 61%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India

Israel
Bulgaria
Japan
Spain
Sweden
Canada
Taiwan
Finland
Portugal
Mexico
Belgium
Hungary
Austria
Brazil
Ukraine
Croatia
Malta
South Korea
South Africa
Denmark
Czech Republic
Malaysia
Argentina
Poland
Cameroon
Australia
Hong Kong
Slovakia
Latvia

20 FDA-registered drug labelers

Alembic Pharmaceuticals Inc.

Alembic Pharmaceuticals Limited

Armas Pharmaceuticals Inc.

Aurobindo Pharma Limited

AX Pharmaceutical Corp

Camber Pharmaceuticals, Inc.

Cambrex Charles City, Inc

Cipla Ltd.

F.I.S. FABBRICA ITALIANA SINTETICI S.P.A.

Hetero Labs Limited

MSN Laboratories Private Limited

Natco Pharma Limited

Novadoz Pharmaceuticals LLC

SHILPA PHARMA LIFESCIENCES LIMITED

Sichuan Xieli Pharmaceutical Co., Ltd.

Sicor de Mexico S.A. de C.V

Teva Pharmaceuticals USA, Inc.

VALARY LAB LIMITED

Zydus Lifesciences Limited

Zydus Pharmaceuticals USA Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Erlotinib Hydrochloride
•Erlotinib

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS183319-69-9

PubChem CID176871

DTXSIDDTXSID10171412

FormulaC22H24ClN3O4

Mol. Weight429.9 g/mol

SMILESCOCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC.Cl

Data Sources

PubChem · compound 176871Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Erlotinib hydrochloride (CAS 183319-69-9) https://chemicalindependence.com/chemical/183319-69-9/ PubChem: 176871. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/176871 FDA National Drug Code directory: CAS 183319-69-9. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293359 for CAS 183319-69-9. Reporting year: 2024. https://usatrade.census.gov/