Repotrectinib

Drug ingredient

CAS 1802220-02-5

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$6.4B

Top sourceSingapore 36%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293499 · basket

These shares come from HS customs code 293499, which covers 575 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

SG 36%SingaporeIE 23%IrelandCN 11%ChinaCH 6%SwitzerlandIN 5%India

Finland
Netherlands
Canada
Indonesia
Mexico
Taiwan
South Korea
Austria
Croatia
Sweden
Ukraine
Denmark
Israel
Czech Republic
New Zealand
Hong Kong
Kyrgyzstan
Australia
Portugal
South Africa
Poland
Slovenia
Brazil
Slovakia
Vietnam
Latvia
Malta
Hungary
Romania
Kenya
Belarus
Russia
Turkey
Norway

6 FDA-registered drug labelers

Asymchem Laboratories (Tianjin) Co., Ltd.

E.R. Squibb & Sons, L.L.C.

Lonza AG

Micro-Macinazione SA

Patheon Inc.

Siegfried Evionnaz SA

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Augtyro

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS1802220-02-5

PubChem CID135565923

DTXSIDDTXSID001358953

FormulaC18H18FN5O2

Mol. Weight355.4 g/mol

SMILESCC1CNC(=O)C2=C3N=C(C=CN3N=C2)NC(C4=C(O1)C=CC(=C4)F)C

Data Sources

PubChem · compound 135565923Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Repotrectinib (CAS 1802220-02-5) https://chemicalindependence.com/chemical/1802220-02-5/ PubChem: 135565923. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/135565923 FDA National Drug Code directory: CAS 1802220-02-5. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293499 for CAS 1802220-02-5. Reporting year: 2024. https://usatrade.census.gov/