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Bupivacaine hydrochloride

Drug ingredientActive Shortage

CAS 18010-40-7

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

Molecular structure of 18010-40-7
1 HCl
US productionNot reported
Import value, 2024$1.3B
Top sourceChina 32%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293339 · basket

These shares come from HS customs code 293339, which covers 397 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
CN 32%ChinaIN 15%IndiaDE 10%GermanyBE 9%BelgiumCH 8%Switzerland
42 FDA-registered drug labelers
A-S Medication Solutions
Abhilasha Pharma Pvt. Ltd.
Apex Healthcare Limited
Asclemed USA, Inc.
AX Pharmaceutical Corp
B. Braun Medical Inc.
Brookfield Pharmaceuticals, LLC.
Camber Pharmaceuticals, Inc.
Cambrex Karlskoga AB
Cardinal Health 107, LLC
DISHMAN CARBOGEN AMCIS LIMITED
Eugia US LLC
Excella GmbH & Co. KG
Fagron Inc
Fosun Pharma USA Inc.
Fresenius Kabi USA, LLC
Harman Finochem Limited
Henry Schein, Inc
HF Acquisition Co LLC, DBA HealthFirst
Hikma Pharmaceuticals USA Inc.
Hospira, Inc.
Huons Co., Ltd.
LETCO MEDICAL, LLC
Medical Purchasing Solutions, LLC
Medisca Inc.
Meitheal Pharmaceuticals Inc
Moehs Catalana SL
NorthStar RxLLC
ONESOURCE SPECIALTY PHARMA LIMITED
Pharma Source Direct, Inc.
Professional Compounding Centers of America
Professional Compounding Centers of America dba PCCA
ProPharma Distribution
Siegfried Evionnaz SA
Societa Italiana Medicinali Scandicci S.I.M.S., SrL
Solupharm Pharmazeutische Erzeugnisse GmbH
Somerset Therapeutics, LLC
Spectrum Laboratory Products, Inc.
Sportpharm LLC
Sportpharm, Inc. dba Sportpharm
Willow Birch Pharma, LLC
Xellia Pharmaceuticals USA LLC

Why It Matters

Sectors
Health
Downstream Uses

Appears in 19 drug and cosmetic product listings (FDA).

  • •Bupivacaine Hydrochloride
  • •Marcaine with Epinephrine
  • •Bupivacaine Hydrochloride injection, solution
  • •Bupivacaine HCl
  • •Marcaine
  • •Marcaine Spinal
  • •Bupivacaine Hydrochloride and Epinephrine
  • •Bupivicaine Hydrochloride
Show all 19
  • •Sensorcaine MPF
  • •Bupivacaine HCI AND Epinephrine
  • •Sensorcaine
  • •Bupivacine HCl
  • •Marvona SUIK
  • •Marvona-25 SUIK
  • •Sensorcaine(R) (Bupivacaine HCI AND Epinephrine)
  • •Bupivacaine Hydrochloride with Dextrose
  • •Bupivacaine HCI
  • •Bupivacaine Spinal
  • •0.25% Bupivacaine HCl
FDA Shortage Status
Active Shortage
Shortage History
  • Current shortage

    Bupivacaine Hydrochloride Injection

    Shortage listed since February 20, 2018

    Manufacturer reports: 1 unavailable, 1 available

  • Current shortage

    Bupivacaine Hydrochloride, Epinephrine Bitartrate Injection

    Shortage listed since February 20, 2018

    Manufacturer reports: 1 unavailable, 1 available

See all current drug shortages

Chemical Identity

CAS18010-40-7
PubChem CID64737
DTXSIDDTXSID0030877
FormulaC18H29ClN2O
Mol. Weight324.9 g/mol
SMILESCCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.Cl

Data Sources

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Brief citations

Bupivacaine hydrochloride (CAS 18010-40-7) https://chemicalindependence.com/chemical/18010-40-7/ PubChem: 64737. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/64737 FDA National Drug Code directory: CAS 18010-40-7. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 18010-40-7. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293339 for CAS 18010-40-7. Reporting year: 2024. https://usatrade.census.gov/