Ambrisentan

Drug ingredient

CAS 177036-94-1

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$7.6B

Top sourceIreland 61%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India

Israel
Bulgaria
Japan
Spain
Sweden
Canada
Taiwan
Finland
Portugal
Mexico
Belgium
Hungary
Austria
Brazil
Ukraine
Croatia
Malta
South Korea
South Africa
Denmark
Czech Republic
Malaysia
Argentina
Poland
Cameroon
Australia
Hong Kong
Slovakia
Latvia

19 FDA-registered drug labelers

A-S Medication Solutions

Actavis Pharma, Inc.

Apotex Corp.

Aurobindo Pharma Limited

Cipla Ltd.

Cipla USA Inc.

Gilead Sciences, Inc.

Golden State Medical Supply, Inc.

Matrix Pharmacorp Private Limited

Medichem Manufacturing (Malta) Ltd.

MSN Laboratories Private Limited

Mylan Pharmaceuticals Inc.

Quallent Pharmaceuticals Health LLC

Sigmapharm Laboratories, LLC

Sun Pharmaceutical Industries, Inc.

Veranova, L.P.

Zhejiang Huahai Pharmaceutical Co., Ltd.

Zydus Lifesciences Limited

Zydus Pharmaceuticals USA Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Ambrisentan
•Letairis

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS177036-94-1

PubChem CID6918493

DTXSIDDTXSID4046282

FormulaC22H22N2O4

Mol. Weight378.4 g/mol

SMILESCC1=CC(=NC(=N1)OC(C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C

Data Sources

PubChem · compound 6918493Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Ambrisentan (CAS 177036-94-1) https://chemicalindependence.com/chemical/177036-94-1/ PubChem: 6918493. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/6918493 FDA National Drug Code directory: CAS 177036-94-1. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293359 for CAS 177036-94-1. Reporting year: 2024. https://usatrade.census.gov/