tapentadol hydrochloride

Drug ingredient

CAS 175591-09-0

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 175591-09-0 — 1 HCl

US productionNot reported

Import value, 2024$64M

Top sourceChina 52%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292229 · basket

These shares come from HS customs code 292229, which covers 84 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 52%ChinaJP 25%JapanIN 18%IndiaIT 3%ItalyKR 1%South Korea

United Kingdom
Ukraine
Canada
Switzerland
Ireland
Netherlands
Israel
Singapore
Latvia
Hong Kong
Belgium

8 FDA-registered drug labelers

Collegium Pharmaceutical, Inc.

Curia Missouri, Inc.

EPIC PHARMA LLC

Hikma Pharmaceuticals USA Inc.

Janssen Pharmaceutical Sciences Unlimited Company

Pisgah Laboratories Inc

S&B Pharma LLC dba Norac Pharma

Siegfried USA, LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 4 drug and cosmetic product listings (FDA).

•Nucynta
•Nucynta ER
•Tapentadol Hydrochloride
•Tapentadol

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS175591-09-0

PubChem CID9838021

DTXSIDDTXSID00938677

FormulaC14H24ClNO

Mol. Weight257.8 g/mol

SMILESCCC(C1=CC(=CC=C1)O)C(C)CN(C)C.Cl

Data Sources

PubChem · compound 9838021Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

tapentadol hydrochloride (CAS 175591-09-0) https://chemicalindependence.com/chemical/175591-09-0/ PubChem: 9838021. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/9838021 FDA National Drug Code directory: CAS 175591-09-0. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 292229 for CAS 175591-09-0. Reporting year: 2024. https://usatrade.census.gov/