Tadalafil

Drug ingredient

CAS 171596-29-5

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$6.4B

Top sourceSingapore 36%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293499 · basket

These shares come from HS customs code 293499, which covers 575 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

SG 36%SingaporeIE 23%IrelandCN 11%ChinaCH 6%SwitzerlandIN 5%India

Finland
Netherlands
Canada
Indonesia
Mexico
Taiwan
South Korea
Austria
Croatia
Sweden
Ukraine
Denmark
Israel
Czech Republic
New Zealand
Hong Kong
Kyrgyzstan
Australia
Portugal
South Africa
Poland
Slovenia
Brazil
Slovakia
Vietnam
Latvia
Malta
Hungary
Romania
Kenya
Belarus
Russia
Turkey
Norway

92 FDA-registered drug labelers

A-S Medication Solutions

Accord Healthcare Inc.

Actelion Pharmaceuticals US, Inc.

Advanced Rx of Tennessee, LLC

Ajanta Pharma USA Inc.

Alembic Pharmaceuticals Inc.

Alembic Pharmaceuticals Limited

Alivus Life Sciences Limited

Ami Lifesciences Private Limited

Amneal Pharmaceuticals Co. (I) Pvt. Ltd.

Amneal Pharmaceuticals NY LLC

Amoli Organics (A Division of Umedica Laboratories Private Limited)

Amoli Organics (A Division of Umedica Laboratories Pvt.Ltd.)

ANI Pharmaceuticals, Inc.

Aphena Pharma Solutions - Tennessee, LLC

Asclemed USA, Inc.

Assia Chemical Industries Ltd - Teva Tech Site

Aurobindo Pharma Limited

AURORE PHARMACEUTICALS PRIVATE LIMITED

AvKARE

AX Pharmaceutical Corp

Azico Biophore India Private Limited

Bostal LLC

Bryant Ranch Prepack

Burel Pharmaceuticals, LLC

Camber Pharmaceuticals, Inc.

Cipla USA Inc.

CMP Pharma, Inc.

CoreRx, Inc.

Cutyx Research LLP

Darmerica

direct rx

Dr.Reddys Laboratories Inc

Eli Lilly and Company

Evonik Corporation

Fagron Inc

FOURRTS (INDIA) LABORATORIES PRIVATE LIMITED

Galenova Inc

Guangzhou Yixin Cross-border E-commerce Co., Ltd.

HEC Pharm USA Inc.

Honour Lab Limited

HORSTER BIOTEK PVT LTD.

HORSTER LIFE SCIENCE PVT LTD

Jubilant Pharmova Limited

Kalchem International inc

LETCO MEDICAL, LLC

Lilly del Caribe, Inc.

Lupin Pharmaceuticals, Inc.

Macleods Pharmaceuticals Limited

Maithili Life Sciences Private Limited

MEDISCA Inc.

MSN Organics Private Limited

NIVAGEN PHARMACEUTICALS, INC.

NorthStar RxLLC

Northwind Health Company, LLC

NuCare Pharmaceutical,Inc.

NuCare Pharmaceuticals, Inc.

OPELLA HEALTHCARE INTERNATIONAL SAS

PD-RX Pharmaceuticals, Inc.

PENN PHARMACEUTICAL SERVICES LIMITED

Pharma Source Direct, Inc.

Preferred Pharmaceuticals Inc.

Professional Compounding Centers of America

Proficient Rx LP

Qilu Pharmaceutical Co., Ltd.

Quallent Pharmaceuticals Health LLC

REMEDYREPACK INC.

SCH Global Services Private Limited

SHOOLIN PHARMA CHEM LLP

SMS Pharmaceuticals Limited

Solco Healthcare US, LLC

Srini Pharmaceuticals Private Limited

SUN PHARMACEUTICAL INDUSTRIES, INC.

Synergene Active Ingredients Private Limited

Teva Pharmaceuticals USA, Inc.

Teva Pharmaceuticals, Inc.

Torrent Pharmaceuticals Limited

Umedica Laboratories USA Inc.

Unichem Laboratories Limited, India

Unichem Pharmaceuticals (USA), Inc.

United Therapeutics Corporation

Upsher-Smith Laboratories, LLC

VKT Pharma Private Limited

Willow Birch Pharma, Inc

Xenex Laboratories Inc

Xinshu Technology Co., Limited

XLCare Pharmaceuticals Inc.

ZAKLADY FARMACEUTYCZNE POLPHARMA S A

Zhejiang Bamboo Pharmaceuticals Co.,Ltd

Zhejiang Huahai Pharmaceutical Co., Ltd.

Zydus Lifesciences Limited

Zydus Pharmaceuticals USA Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 8 drug and cosmetic product listings (FDA).

•Tadalafil
•Esokalli Testosterone Booster Oral Dissolving Film
•Opsynvi
•Cialis
•ALYQ
•CHBO
•Adcirca
•Tadliq

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$1.21/gApollo Scientific UK

CountryUnited Kingdom

Pack$3024.00 / 2.5 kg

Purity99%

Vendors4 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

3 more vendors

Vendor	Country	$/g	Pack	Purity
Vitas M Chemical Limited	Hong Kong	$13867.49	10 μmol	90%
TargetMol Chemicals	China → United States	$15800.00	100 mg	99.89%
Princeton BioMolecular Research (SC)	United States	$18000.00	5 mg	90%

Chemical Identity

CAS171596-29-5

PubChem CID110635

DTXSIDDTXSID9046786

FormulaC22H19N3O4

Mol. Weight389.4 g/mol

SMILESCN1CC(=O)N2C(C1=O)CC3=C(C2C4=CC5=C(C=C4)OCO5)NC6=CC=CC=C36

Data Sources

PubChem · compound 110635Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Tadalafil (CAS 171596-29-5) https://chemicalindependence.com/chemical/171596-29-5/ PubChem: 110635. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/110635 FDA National Drug Code directory: CAS 171596-29-5. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293499 for CAS 171596-29-5. Reporting year: 2024. https://usatrade.census.gov/